Toxicology USMLE Step 1 Practice Question
A 43-year-old woman with breast cancer receiving doxorubicin presents with progressive dyspnea and fatigue. Vital signs show BP 128/82 mmHg, HR 102 bpm, RR 18/min, and SpO2 98% on room air. Echocardiography reveals a declining left ventricular ejection fraction of 35% (previously 55%). Troponin is mildly elevated at 0.08 ng/mL. She denies chest pain. Which agent can reduce the risk of this doxorubicin-induced cardiotoxicity?
Answer choices
- ALeucovorin
- BProtamine sulfate
- CSuccimer
- DMesna
- EDexrazoxaneCorrect answer
- FAmifostine
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