Chronic Kidney Disease USMLE Step 1 Practice Questions
66 board-style USMLE Step 1 questions in Nephrology. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 · medium1. A 70-year-old woman comes to the physician because of a 4-month history of fatigue, worsening swelling of her ankles, and a 5-kg (11-lb) weight gain. Neurologic examination show…
- USMLE Step 1 · hard2. A 52-year-old woman presents with rapidly progressive renal failure and hematuria. Vital signs show BP 158/92 mmHg, HR 98/min, RR 20/min, Temp 37.2°C, SpO2 98% on room air. Seru…
- USMLE Step 1 · medium3. A 4-year-old girl develops bloody diarrhea after consuming undercooked beef at a picnic. Five days later, she presents with pallor and oliguria. Vital signs show BP 142/88 mmHg,…
- USMLE Step 1 · easy4. A 36-year-old woman presents with progressive facial puffiness and bilateral ankle edema over 3 weeks. Vital signs: BP 142/88 mmHg, HR 88/min, RR 16/min, temp 37°C, SpO2 98%. Ur…
- USMLE Step 1 · medium5. A 63-year-old man with diffuse atherosclerosis and poorly controlled hypertension (BP 178/104 mmHg, HR 88/min) presents with a systolic abdominal bruit. Serum creatinine rises f…
- USMLE Step 1 · medium6. A full-term newborn presents with severe respiratory distress within 2 hours of birth. Vital signs show tachypnea (RR 68/min), tachycardia (HR 168/min), and hypoxemia (SpO2 88%…
- USMLE Step 1 · easy7. A 41-year-old man presents with hypertension (BP 158/96 mmHg, HR 88/min) and bilateral flank fullness. His father required dialysis at age 52. Physical examination reveals palpa…
- USMLE Step 1 · medium8. A 44-year-old woman with a history of recurrent urinary tract infections presents with fever (38.9°C), dysuria, and left flank pain. Vital signs show BP 128/82 mmHg, HR 102/min,…
- USMLE Step 1 · easy9. A 66-year-old woman with stage 3 chronic kidney disease presents with progressive fatigue and decreased exercise tolerance. Vital signs: BP 148/92, HR 88, RR 16, Temp 37.2°C, Sp…
- USMLE Step 1 · hard10. A 59-year-old man with stage 4 chronic kidney disease presents with diffuse bone pain and pruritus. Vital signs: BP 148/92 mmHg, HR 88/min, RR 16/min, temp 37°C. Laboratory stud…
- USMLE Step 1 · easy11. A 48-year-old man presents with severe hemorrhage following a motor vehicle collision. Vital signs show BP 85/52, HR 118, RR 22, SpO2 98% on room air. Serum creatinine is 2.1 mg…
- USMLE Step 1 · hard12. A 62-year-old woman with stage 3b CKD on lisinopril presents with volume depletion following aggressive diuresis. Vitals show BP 98/62, HR 102, RR 18, temp 37°C. Serum creatinin…
- USMLE Step 1 · medium13. A 35-year-old male presents with severe dehydration following prolonged exercise without fluid intake. Vital signs show BP 95/60, HR 118, RR 20, and serum osmolality 310 mOsm/kg…
- USMLE Step 1 · hard14. A 45-year-old man with stage 3b chronic kidney disease (eGFR 34 mL/min/1.73m²) presents with BP 148/92 mmHg, HR 78/min, RR 16/min. Serum creatinine is 2.1 mg/dL with normal urin…
- USMLE Step 1 · hard15. A 75 year old nursing home resident is brought in for confusion after several days of poor oral intake. Blood pressure is 88/54 mm Hg. Creatinine is mildly elevated. His urine s…
- USMLE Step 1 · hard16. A 68-year-old man with stage 3b chronic kidney disease (eGFR 34 mL/min/1.73m²) presents for research study participation. Vital signs: BP 142/88 mmHg, HR 76/min, RR 14/min, Temp…
- USMLE Step 1 · hard17. A 58-year-old man with chronic kidney disease presents with fatigue and dyspnea. Vital signs: BP 156/92 mmHg, HR 88/min, RR 18/min, SpO2 98% on room air. Serum creatinine is 3.2…
- USMLE Step 1 · medium18. A 70 year old man with severe systolic heart failure presents with progressive dyspnea, bibasilar crackles, and lower extremity edema. He is being considered for an osmotic diur…
- USMLE Step 1 · medium19. A 28-year-old man presents for evaluation before a high-altitude mountaineering expedition. Vital signs: BP 118/76 mmHg, HR 72 bpm, RR 16 breaths/min, SpO2 98% at sea level. He…
- USMLE Step 1 · easy20. A 56-year-old man with resistant hypertension (BP 168/104 mmHg) and primary hyperaldosteronism (plasma aldosterone 24 ng/dL, renin suppressed) started spironolactone 25 mg daily…
- USMLE Step 1 · medium21. A 39-year-old woman presents with recurrent calcium oxalate kidney stones despite increased fluid intake and compliance with dietary modifications. Vital signs are stable (BP 12…
- USMLE Step 1 · medium22. A 67-year-old woman with acute decompensated heart failure presents with dyspnea and orthopnea. Vital signs: BP 160/95, HR 110, RR 22, SpO2 88%. She receives high-dose intraveno…
- USMLE Step 1 · medium23. A 46-year-old man with bipolar disorder presents with polyuria and polydipsia. He has taken lithium for 8 years. Vital signs show BP 138/82 mmHg, HR 88/min, RR 16/min, temp 37°C…
- USMLE Step 1 · easy24. A 31-year-old woman presents with polyuria and intense polydipsia two weeks after transsphenoidal pituitary adenoma resection. Vital signs show HR 98/min, BP 138/82 mmHg, RR 16/…