Chronic Kidney Disease USMLE Step 1 Practice Question
A 48-year-old man presents with severe hemorrhage following a motor vehicle collision. Vital signs show BP 85/52, HR 118, RR 22, SpO2 98% on room air. Serum creatinine is 2.1 mg/dL with BUN 48 mg/dL. Urinalysis shows muddy brown casts. He denies previous kidney disease. Which renal cells directly synthesize and release renin in response to the decreased renal perfusion pressure from his acute blood loss?
Answer choices
- APodocytes lining the visceral Bowman capsule
- BMesangial cells of the glomerulus
- CAlpha intercalated cells of the collecting duct
- DJuxtaglomerular granular cells of the afferent arterioleCorrect answer
- EMacula densa cells of the distal tubule
- FExtraglomerular mesangial cells (lacis cells) within the juxtaglomerular apparatus
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