Chronic Kidney Disease USMLE Step 1 Practice Question
A 52-year-old woman presents with rapidly progressive renal failure and hematuria. Vital signs show BP 158/92 mmHg, HR 98/min, RR 20/min, Temp 37.2°C, SpO2 98% on room air. Serum creatinine is 4.2 mg/dL with RBC casts on urinalysis. She reports recurrent sinusitis and persistent cough but denies hemoptysis. Kidney biopsy demonstrates crescentic glomerulonephritis with minimal immune deposition on immunofluorescence. Which antibody is most likely present?
Answer choices
- Ac ANCA directed against proteinase 3Correct answer
- BAnti phospholipase A2 receptor antibodies
- CAnti mitochondrial antibodies
- DAnti double stranded DNA antibodies
- EAnti glomerular basement membrane antibodies
- Fp ANCA directed against myeloperoxidase
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