Chronic Kidney Disease USMLE Step 1 Practice Question
A 4-year-old girl develops bloody diarrhea after consuming undercooked beef at a picnic. Five days later, she presents with pallor and oliguria. Vital signs show BP 142/88 mmHg, HR 118/min, RR 22/min, and Temp 37.2Ā°C. Laboratory studies reveal hemoglobin 7.2 g/dL with schistocytes on blood smear, platelets 45,000/Ī¼L, creatinine 2.8 mg/dL, and normal coagulation studies. Urinalysis shows no proteinuria. Which of the following is the most likely cause?
Answer choices
- AImmune complex deposition after streptococcal infection
- BDeficiency of ADAMTS13 metalloprotease
- CAutoantibodies to glomerular basement membrane collagen
- DShiga like toxin mediated endothelial injuryCorrect answer
- ESevere vitamin K deficiency
- FAtypical HUS from complement regulatory protein mutations
See the full explanation
Get the correct-answer rationale, why each distractor is wrong, the underlying mechanism, and high-yield associations ā plus adaptive practice that targets your weak areas ā with a free MedBoardPRO account.