Diabetes Mellitus USMLE Step 1 Practice Questions
84 board-style USMLE Step 1 questions in Endocrinology. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 · medium25. A 29-year-old man presents with recurrent peptic ulcers from a gastrin-secreting pancreatic tumor. He has symptomatic nephrolithiasis secondary to hypercalcemia (calcium 11.2 mg…
- USMLE Step 1 · medium26. A 38-year-old woman presents with episodic pounding headaches, diaphoresis, and palpitations triggered during abdominal surgery. Vital signs show BP 188/112 mmHg, HR 118/min, RR…
- USMLE Step 1 · hard27. A 67-year-old man with severe atherosclerotic disease and type 2 diabetes presents with refractory hypertension despite lisinopril and amlodipine. Vital signs show BP 178/102 mm…
- USMLE Step 1 · easy28. A 44-year-old woman with a 3-year history of hypertension poorly controlled on lisinopril presents with progressive muscle cramps and fatigue. Vital signs show BP 168/102 mmHg,…
- USMLE Step 1 · medium29. A 62 year old man with a long smoking history presents with new onset diabetes, proximal muscle weakness, hypokalemic metabolic alkalosis, and diffuse hyperpigmentation. Cortiso…
- USMLE Step 1 · medium30. A 39 year old woman has weight gain, proximal muscle weakness, easy bruising, facial rounding, and purple abdominal striae. Testing shows elevated 24 hour urinary free cortisol…
- USMLE Step 1 · medium31. A 17-year-old 46,XY phenotypic female with primary amenorrhea presents with BP 152/94 mmHg, HR 88, RR 16, temp 37°C. Labs show cortisol 3 mcg/dL (low), testosterone 18 ng/dL (lo…
- USMLE Step 1 · medium32. A 6-year-old boy presents with early pubic hair development and accelerated linear growth. Vital signs show BP 148/92 mmHg, HR 88/min, RR 18/min, temperature 37°C. Laboratory st…
- USMLE Step 1 · easy33. A 5-day-old female infant with ambiguous external genitalia presents with lethargy and poor feeding. Vital signs reveal BP 68/42 mmHg, HR 158/min, RR 32/min, temperature 36.8°C.…
- USMLE Step 1 · medium34. A 58-year-old woman abruptly discontinues high-dose prednisone used for autoimmune disease. She presents with fatigue, nausea, and abdominal pain. Vital signs show BP 88/54 mmHg…
- USMLE Step 1 · easy35. A 35-year-old woman presents with a 3-month history of chronic fatigue, progressive weight loss, and orthostatic dizziness. She reports intense salt cravings. Vital signs show B…
- USMLE Step 1 · easy36. A 67 year old man with a 50 pack year smoking history is brought for confusion. He has no edema. Serum sodium is 118 mEq/L, serum osmolality is low, and urine osmolality is inap…
- USMLE Step 1 · medium37. A 41-year-old man with bipolar disorder on lithium presents with a 3-month history of polyuria and nocturia. Vital signs: BP 128/82, HR 88, RR 16, Temp 37°C, SpO2 98%. Labs show…
- USMLE Step 1 · medium38. A 24 year old man develops severe polyuria and polydipsia 3 days after transsphenoidal surgery for a pituitary adenoma. Serum sodium is 152 mEq/L and urine osmolality is low. Ad…
- USMLE Step 1 · medium39. A 32 year old woman is brought for evaluation 2 weeks after a complicated delivery with massive postpartum hemorrhage. She is unable to breastfeed and feels weak and lightheaded…
- USMLE Step 1 · medium40. A 46-year-old man presents with progressive hand and jaw enlargement, frontal headaches, and visual field defects. Vital signs show BP 158/92 mmHg, HR 88/min, RR 16/min, tempera…
- USMLE Step 1 · medium41. A 29-year-old woman presents with 6 months of irregular menses and bilateral milky nipple discharge. She takes risperidone for schizophrenia. Vital signs: BP 118/76, HR 82, RR 1…
- USMLE Step 1 · hard42. A 28-year-old woman with chronic anxiety drinks more than 8 liters of water per day. She has frequent urination. Serum sodium is 129 mEq/L and serum osmolality is low. During wa…
- USMLE Step 1 · hard43. A 49-year-old woman with type 2 diabetes presents with profuse watery diarrhea persisting despite 24-hour fasting, muscle weakness, and facial flushing. Vital signs show BP 118/…
- USMLE Step 1 · hard44. A 56-year-old woman with poorly controlled type 2 diabetes mellitus presents with a 3-week history of weight loss and perioral stomatitis. Vital signs: BP 138/82, HR 92, RR 18,…
- USMLE Step 1 · hard45. A 43-year-old woman presents with recurrent episodes of diaphoresis, tremor, and confusion that resolve after consuming juice. Vital signs show HR 102, BP 138/88, RR 16, temp 37…
- USMLE Step 1 · medium46. A 45-year-old man presents with episodic severe headaches, diaphoresis, and palpitations. Vital signs show BP 168/102 mmHg, HR 118 bpm, RR 16/min, temp 37.2°C. Physical examinat…
- USMLE Step 1 · medium47. A 52-year-old man with type 2 diabetes mellitus presents with hypertension (BP 168/104 mmHg, HR 92/min, RR 16/min). Laboratory studies show serum glucose 287 mg/dL and elevated…
- USMLE Step 1 · hard48. A 16-year-old phenotypic female with 46,XY karyotype presents for evaluation of primary amenorrhea. She has scant pubic hair, absent breast development, and denies medications.…