Viral Infections USMLE Step 1 Practice Questions
57 board-style USMLE Step 1 questions in Infectious Disease. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 · medium1. A 34-year-old female epidemiologist working at a port authority in Taiwan presents to occupational health after discovering a shipment of poultry from mainland China with confir…
- USMLE Step 1 · easy2. A 64-year-old man with type 2 diabetes mellitus presents to the clinic with a 2-day history of severe burning pain along his right mid-thoracic region. He describes the pain as…
- USMLE Step 1 · medium3. A 20-year-old woman presents to urgent care with a 5-day history of severe pharyngitis, malaise, and fever. She reports that her roommate was ill with similar symptoms 3 weeks a…
- USMLE Step 1 · medium4. An 11-year-old girl is brought to the clinic by her mother with a 3-day history of an erythematous rash on her trunk and extremities. The mother reports that 1 week ago, the pat…
- USMLE Step 1 · medium5. A 44-year-old man with a history of HIV infection presents to clinic for evaluation of a new skin lesion. He reports poor adherence to antiretroviral therapy for the past 18 mon…
- USMLE Step 1 · hard6. A 5-year-old previously unvaccinated boy presents to clinic with a 3-day history of fever (39.2°C), sore throat, and malaise. His mother reports a maculopapular rash that began…
- USMLE Step 1 · medium7. A 28-year-old previously healthy woman presents with fever, severe headache, neck stiffness, and confusion for 24 hours. CSF analysis shows lymphocytic pleocytosis with normal g…
- USMLE Step 1 · medium8. A 4-year-old boy presents with fever (38.9°C), barky cough, and inspiratory stridor. Vital signs show HR 115/min, RR 28/min, BP 105/68 mmHg, and SpO2 98% on room air. Lateral ne…
- USMLE Step 1 · medium9. A 32-year-old woman at 8 weeks gestation presents to clinic with a 3-day history of low-grade fever (38.5°C), fine maculopapular rash beginning on the face and spreading to the…
- USMLE Step 1 · medium10. A 65-year-old man with chickenpox history presents with painful vesicular rash in T5 dermatomal distribution, fever (38.2°C), and malaise. Vital signs show BP 138/82, HR 88, RR…
- USMLE Step 1 · hard11. A 32-year-old HIV-positive patient with a CD4 count of 28 cells/μL presents with progressive vision loss and floaters. Vital signs are stable; temperature is 37.2°C. Fundoscopic…
- USMLE Step 1 · medium12. A 28-year-old woman presents to the emergency department 3 days after returning from travel to Southeast Asia. She reports fever (39.2°C), severe retro-orbital headache, myalgia…
- USMLE Step 1 · medium13. A 45-year-old man with a history of hepatitis C-related cirrhosis presents to the emergency department with acute dyspnea and hemoptysis that began 6 hours ago. He reports no fe…
- USMLE Step 1 · medium14. A 7-year-old boy is brought to the clinic by his mother with a 3-day history of cough, coryza, and conjunctivitis. He developed a low-grade fever (38.5°C) 2 days ago. On examina…
- USMLE Step 1 · hard15. A 62-year-old man with a 15-year history of COPD presents to the emergency department with a 3-day history of fever (39.2°C), productive cough with purulent sputum, dyspnea, and…
- USMLE Step 1 · medium16. A 2-year-old previously healthy boy presents with sudden-onset severe respiratory distress, inspiratory stridor, and cyanosis during sleep. Vital signs show HR 125/min, RR 38/mi…
- USMLE Step 1 · easy17. A 16-year-old boy presents with fever, jaundice, and right upper quadrant abdominal pain for 5 days. His ALT and AST are markedly elevated (3500 and 3200 IU/L respectively), and…
- USMLE Step 1 · medium18. A 22-year-old woman with no significant past medical history presents to the emergency department with a 7-day history of fever, cough productive of blood-tinged sputum, and pro…
- USMLE Step 1 · easy19. A 2-year-old unvaccinated boy presents with a 3-day history of high fever (39.8°C), cough, bilateral conjunctivitis, and coryza. He now develops an erythematous maculopapular ra…
- USMLE Step 1 · hard20. A 45-year-old man from Southeast Asia presents with fever, severe headache, neck stiffness, and photophobia for 4 days. CSF shows lymphocytic pleocytosis (180 WBC, 70% lymphocyt…
- USMLE Step 1 · hard21. A 28-year-old woman with HIV presents to the clinic with a 3-week history of progressive cognitive decline, memory loss, and difficulty concentrating. She denies headache, fever…
- USMLE Step 1 · medium22. A 6-year-old boy is brought to the emergency department with a 3-day history of progressive cough and dyspnea. His mother reports he has been wheezing and has had low-grade feve…
- USMLE Step 1 · easy23. A 32-year-old woman presents with fever, pharyngitis, and exudative tonsils for 3 days. She reports contact with her roommate who had similar symptoms 1 week ago. Rapid strep te…
- USMLE Step 1 · hard24. A 19-year-old man from rural Bangladesh presents to the emergency department with acute-onset flaccid paralysis of both lower extremities and urinary retention. Two weeks prior,…