Viral Infections USMLE Step 1 Practice Questions
57 board-style USMLE Step 1 questions in Infectious Disease. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 · easy25. A 5-year-old boy presents with 3 days of high fever (39.8°C) followed by a diffuse maculopapular rash on the trunk and face as fever subsides. Vital signs show HR 110/min, RR 24…
- USMLE Step 1 · medium26. A 22-year-old male college student presents to urgent care with a 3-day history of severe sore throat, fever, and malaise. Temperature is 39.5°C, heart rate 102 bpm, respiratory…
- USMLE Step 1 · hard27. A 45-year-old man with HIV infection presents to the emergency department with a 2-week history of progressive visual loss, floaters, and photopsia in his right eye. He denies e…
- USMLE Step 1 · easy28. A 7-year-old boy presents with 3 days of high fever (39.8°C), cough, and rhinorrhea. He now has a characteristic maculopapular rash beginning on the face and spreading downward.…
- USMLE Step 1 · medium29. A 32-year-old woman without significant medical history presents to the emergency department with a 2-day history of fever (39.2°C), severe frontal headache, and neck stiffness.…
- USMLE Step 1 · medium30. A 16-year-old girl presents to the emergency department with a 5-day history of fever, severe sore throat, and dysphagia. Vital signs are temperature 39.2°C, heart rate 102/min,…
- USMLE Step 1 · hard31. A 19-year-old previously healthy college student from the Midwest presents to the emergency department in early September with a 3-day history of high fever (39.8°C), severe fro…
- USMLE Step 1 · medium32. A 72-year-old man with COPD presents to the emergency department with a 5-day history of progressive dyspnea, productive cough with purulent sputum, and fever. Vital signs show…
- USMLE Step 1 · easy33. A 3-year-old boy presents with high fever (104.2°F) for 4 days followed by abrupt defervescence and appearance of a generalized maculopapular rash on the trunk sparing the face.…
- USMLE Step 1 · easy34. A 45-year-old man with no significant past medical history presents with fever, malaise, and headache for 3 days, followed by development of painful vesicles on his lower back i…
- USMLE Step 1 · medium35. A 24-year-old previously healthy woman presents with fever (39.2°C), sore throat, and diffuse lymphadenopathy. She reports taking amoxicillin for pharyngitis 3 days ago. On exam…
- USMLE Step 1 · hard36. A 32 year old woman undergoes colposcopy after a Pap test shows high grade squamous intraepithelial lesion. Biopsy reveals koilocytosis and dysplastic squamous epithelium. She h…
- USMLE Step 1 · hard37. A 41-year-old woman with multiple sclerosis on natalizumab presents with progressive visual deficits, clumsiness, and aphasia over 4 weeks. Vital signs: BP 128/82, HR 88, RR 16,…
- USMLE Step 1 · medium38. A 52-year-old man with a history of injection drug use presents with a 3-week history of fatigue, palpable purpura on his lower extremities, and progressive numbness in his feet…
- USMLE Step 1 · hard39. A 30-year-old surgical resident sustains a needlestick injury from a patient with acute hepatitis. Six weeks later, she presents with malaise, right upper quadrant discomfort, a…
- USMLE Step 1 · medium40. A 28 year old man presents with fever, sore throat, diffuse rash, and tender cervical lymphadenopathy 3 weeks after unprotected sexual intercourse with a new partner. He has ora…
- USMLE Step 1 · medium41. A 7-year-old unimmunized boy presents with fever (39.2°C), pharyngitis, and progressive asymmetric right leg weakness over 3 days. Heart rate is 102 bpm, respiratory rate 18/min…
- USMLE Step 1 · medium42. A 34 year old man presents with agitation, fever, difficulty swallowing, and painful throat spasms when trying to drink water. Two weeks ago he woke up with a bat in his bedroom…
- USMLE Step 1 · easy43. A 72-year-old woman in a nursing facility presents with abrupt onset vomiting and profuse watery diarrhea. Multiple residents and staff developed identical symptoms within 24 ho…
- USMLE Step 1 · easy44. A 10-month-old unvaccinated infant presents in January with profuse watery diarrhea and vomiting for 2 days. He appears lethargic with dry mucous membranes and sunken fontanelle…
- USMLE Step 1 · medium45. A pregnant 24 year old woman who did not receive prenatal care develops a mild febrile illness with posterior auricular lymphadenopathy and a faint rash during the first trimest…
- USMLE Step 1 · medium46. A 19-year-old unvaccinated college student presents with fever (38.8°C), malaise, and bilateral parotid swelling. Two days later, he develops left testicular pain and swelling.…
- USMLE Step 1 · medium47. A 6-year-old unvaccinated boy presents with a 4-day history of high fever (39.8°C), cough, coryza, and conjunctivitis. Physical examination reveals a descending maculopapular ra…
- USMLE Step 1 · medium48. A 26 year old graduate student develops abrupt fever, myalgias, headache, and dry cough during January. Several classmates are similarly ill. Public health officials are concern…