Viral Infections USMLE Step 1 Practice Question
A 19-year-old previously healthy college student from the Midwest presents to the emergency department in early September with a 3-day history of high fever (39.8°C), severe frontal headache, photophobia, and nuchal rigidity. On examination, he is alert but uncomfortable with neck flexion. Kernig and Brudzinski signs are positive. Laboratory studies show WBC 12,500/μL with 85% lymphocytes. Cerebrospinal fluid analysis reveals: WBC 320/μL (92% lymphocytes), protein 95 mg/dL, glucose 28 mg/dL (serum glucose 118 mg/dL), and negative Gram stain. Bacterial culture, enteroviral PCR, and HSV-1/2 PCR are all negative. Which of the following is the most likely viral etiology?
Answer choices
- ACytomegalovirus (CMV)
- BWest Nile virusCorrect answer
- CMumps virus
- DEpstein-Barr virus (EBV)
- EVaricella-zoster virus (VZV)
- FPoliovirus
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