Pituitary Disorders USMLE Step 1 Practice Questions
57 board-style USMLE Step 1 questions in Endocrinology. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 · medium1. A 28-year-old woman presents to clinic 6 months after an uncomplicated vaginal delivery with complaints of progressive fatigue, persistent amenorrhea, and inability to breastfee…
- USMLE Step 1 · hard2. A 32-year-old woman presents with a 3-month history of amenorrhea, galactorrhea, and weight gain. Five months ago, she was started on clozapine 300 mg daily for schizophrenia. S…
- USMLE Step 1 · medium3. A 28-year-old man with acromegaly and elevated IGF-1 (680 ng/mL) undergoes transsphenoidal resection of a growth hormone-secreting pituitary adenoma. Postoperatively, he develop…
- USMLE Step 1 · hard4. A 52-year-old woman presents with acute severe frontal headache, sudden bitemporal hemianopia, and altered mental status. Vital signs reveal BP 88/52 mmHg, HR 118/min, RR 22/min…
- USMLE Step 1 · medium5. A 38-year-old man with prior transsphenoidal pituitary surgery presents with progressive fatigue, weight gain, and hypotension. Vital signs show BP 92/58 mmHg, HR 72/min, RR 16/…
- USMLE Step 1 · medium6. A 45-year-old woman presents with progressive frontal headaches, bitemporal hemianopsia, and galactorrhea for 6 months. Vital signs: BP 128/82 mmHg, HR 76 bpm, RR 14, Temp 37°C.…
- USMLE Step 1 · medium7. A 35-year-old woman presents with polyuria (4 liters daily), polydipsia, and mild hypernatremia (Na+ 147 mEq/L). Serum osmolality is 305 mOsm/kg (elevated), and urine osmolality…
- USMLE Step 1 · easy8. A 51-year-old man presents with decreased libido and erectile dysfunction. Vital signs reveal BP 128/76 mmHg, HR 72 bpm, RR 14/min, temperature 37°C, and SpO2 98% on room air. L…
- USMLE Step 1 · easy9. A 45-year-old woman presents with progressive cold intolerance, weight gain, hair loss, and fatigue over 6 months. Vital signs show HR 52 bpm, BP 128/82 mmHg, temperature 36.2°C…
- USMLE Step 1 · hard10. A 67-year-old man with severe hypertension (BP 178/104 mmHg) and hypokalemia (K+ 2.8 mEq/L) undergoes evaluation. Morning cortisol is 42 mcg/dL (normal <20), ACTH is 8 pg/mL (no…
- USMLE Step 1 · hard11. A 29-year-old man with type 1 diabetes presents with sudden-onset severe frontal headache, fever (39.2°C), and altered mental status. Vital signs show BP 118/76, HR 104, RR 18,…
- USMLE Step 1 · hard12. A 72-year-old man with hypertension and diabetes presents with progressive memory loss, confusion, and polyuria over 6 months. Serum sodium is 118 mEq/L (normal 135-145). Urine…
- USMLE Step 1 · medium13. A 34-year-old woman with a history of postpartum hemorrhage 2 years ago now presents with fatigue, cold intolerance, amenorrhea, and hypotension. Laboratory findings show low TS…
- USMLE Step 1 · medium14. A 38-year-old woman reports weakness, polyuria, polydipsia, and hypertension. Laboratory evaluation shows hypokalemia (K+ 2.9 mEq/L), metabolic alkalosis, and elevated 24-hour u…
- USMLE Step 1 · medium15. A 56-year-old man with hypertension on lisinopril presents with severe frontal headache, neck stiffness, and sudden-onset bitemporal hemianopsia. Vital signs: BP 158/92 mmHg, HR…
- USMLE Step 1 · medium16. A 42-year-old woman presents with progressive frontal headaches and amenorrhea for 8 months. Vital signs show BP 128/82, HR 78, RR 16, temperature 37°C, SpO2 98%. Physical exami…
- USMLE Step 1 · medium17. A 35-year-old woman on chlorpromazine for schizophrenia presents with amenorrhea, infertility, and galactorrhea. Vital signs: BP 118/76, HR 82, RR 14, Temp 37°C, SpO2 98%. Prola…
- USMLE Step 1 · hard18. A 37-year-old man with hypertension presents with hypokalemia and metabolic alkalosis. Vital signs show BP 158/96 mmHg, HR 88, RR 14, temp 37°C, SpO2 98%. Laboratory studies rev…
- USMLE Step 1 · hard19. A 54-year-old woman undergoes pituitary surgery for a non-functioning macroadenoma. On postoperative day 1, she develops polyuria (800 mL/hour) and severe thirst. Vital signs sh…
- USMLE Step 1 · medium20. A 19-year-old man with Marfan syndrome presents with acute-onset polyuria (10 L/day) and polydipsia. Vital signs: BP 118/76, HR 88, RR 16, temp 37°C, SpO2 98%. Labs show serum o…
- USMLE Step 1 · easy21. A 41-year-old woman with diabetes mellitus presents with progressive coarse facial features, hand enlargement, and excessive sweating. Her fasting glucose is 180 mg/dL despite h…
- USMLE Step 1 · easy22. A 28-year-old man presents with tall stature, long limbs, and gynecomastia. Vital signs show BP 118/76, HR 72, RR 16, temp 37°C. Physical examination reveals small firm testes a…
- USMLE Step 1 · medium23. A 68-year-old man with a history of pituitary surgery 10 years ago presents with progressive fatigue and generalized weakness. Vital signs show BP 105/68 mmHg, HR 82/min, RR 16/…
- USMLE Step 1 · medium24. A 52-year-old woman with sudden onset severe headache, neck stiffness, and visual disturbance is found to have a sellar mass on MRI with evidence of hemorrhage. Her serum sodium…