Histology USMLE Step 1 Practice Questions
54 board-style USMLE Step 1 questions in Anatomy. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 · medium1. A 51-year-old woman presents with a 6-month history of postprandial epigastric discomfort and bloating. Over the past 3 months, she has developed progressive paresthesias in her…
- USMLE Step 1 · medium2. A 54-year-old woman presents with a 2-month history of recurrent, painful erosions of the oral mucosa and a 1-week history of flaccid blisters on the flexural surfaces of her tr…
- USMLE Step 1 · medium3. A 45-year-old woman undergoes a liver biopsy for suspected cirrhosis. Microscopic examination reveals extensive fibrosis with bridging between portal tracts and central veins, a…
- USMLE Step 1 · easy4. A 52-year-old man with a 30-year history of occupational asbestos exposure presents to clinic with progressive dyspnea and pleuritic chest pain over the past 6 months. Vital sig…
- USMLE Step 1 · hard5. A 45-year-old man with chronic kidney disease presents with edema and proteinuria. Vital signs show BP 145/92 mmHg, HR 88/min, RR 16/min, and temperature 37°C. Serum creatinine…
- USMLE Step 1 · medium6. A 28-year-old male presents with a 10-year history of chronic heartburn and regurgitation unresponsive to lifestyle modification. Upper endoscopy reveals salmon-pink discolorati…
- USMLE Step 1 · medium7. A 34-year-old woman with a 10-year history of hepatitis C presents with jaundice, ascites, and spider angiomas. Vital signs show BP 110/68 mmHg, HR 92/min, RR 16/min, temp 37.2°…
- USMLE Step 1 · easy8. A 19-year-old male presents to dermatology with severe acne vulgaris affecting the face, chest, and back for the past 8 months. He reports multiple inflamed papules and comedone…
- USMLE Step 1 · medium9. A 45-year-old man with a 20-year history of heavy alcohol consumption presents to the clinic with progressive jaundice and right upper quadrant discomfort. He reports increased…
- USMLE Step 1 · medium10. A 7-year-old boy is evaluated for short stature. His height is at the 3rd percentile for age, and radiographs show delayed epiphyseal closure in long bones. Serum growth hormone…
- USMLE Step 1 · medium11. A 34-year-old woman presents with a 3-month history of progressive polyarticular joint pain and morning stiffness lasting more than 2 hours. Physical examination reveals symmetr…
- USMLE Step 1 · easy12. A 72-year-old man presents with progressive nocturia (×4 per night) and a diminished urinary stream over 3 years. He reports incomplete emptying but denies dysuria, hematuria, o…
- USMLE Step 1 · hard13. A 31-year-old man with achondroplasia presenting with severe growth retardation is evaluated further. Vital signs show BP 118/76, HR 82, RR 16, temp 37°C, SpO2 98%. He denies jo…
- USMLE Step 1 · medium14. A 67-year-old man with a 40 pack-year smoking history presents with progressive dysphagia and unintentional 12-lb weight loss over 2 months. Endoscopy reveals an irregular, ulce…
- USMLE Step 1 · medium15. A 19-year-old female college student presents with a 2-day history of fever (39.2°C), petechial rash on her lower extremities and trunk, and progressive confusion. Vital signs:…
- USMLE Step 1 · hard16. A 28-year-old man presents with hemoptysis and dyspnea. Vital signs show BP 128/82 mmHg, HR 102/min, RR 22/min, temperature 37.2°C, and SpO2 88% on room air. Chest X-ray reveals…
- USMLE Step 1 · medium17. A 52-year-old man with a 20-year history of alcohol use disorder presents to clinic with progressive abdominal distension and lower extremity edema. He reports fatigue and early…
- USMLE Step 1 · easy18. A 16-year-old girl presents to dermatology with a 6-month history of facial acne consisting of comedones, inflammatory papules, and pustules distributed across her forehead, che…
- USMLE Step 1 · medium19. A 28-year-old man with Crohn disease presents with abdominal pain and diarrhea. Vital signs: BP 118/76, HR 88, RR 16, Temp 37.8°C, SpO2 98%. Colonoscopy with biopsy of inflamed…
- USMLE Step 1 · hard20. A 42-year-old woman presents to otolaryngology with progressive bilateral low-frequency sensorineural hearing loss over the past 5 years. She reports a family history of similar…
- USMLE Step 1 · easy21. A 58-year-old man with a 15-year history of gastroesophageal reflux disease presents for surveillance upper endoscopy. He reports persistent heartburn despite daily omeprazole t…
- USMLE Step 1 · medium22. A 52-year-old man with a 10-year history of hepatitis B cirrhosis presents with right upper quadrant pain and weight loss. Vital signs are stable. Serum alpha-fetoprotein is 520…
- USMLE Step 1 · medium23. A 65-year-old man with a 40-pack-year smoking history presents with hemoptysis, progressive dyspnea, and unintentional weight loss over 3 months. Chest X-ray demonstrates a 3-cm…
- USMLE Step 1 · medium24. A 35-year-old woman with a known pituitary adenoma undergoes surgery. Histologic examination of the resected tissue reveals polygonal cells with eccentric nuclei and basophilic…