Histology USMLE Step 1 Practice Question
A 72-year-old man presents with progressive nocturia (×4 per night) and a diminished urinary stream over 3 years. He reports incomplete emptying but denies dysuria, hematuria, or fever. Vital signs are normal. Digital rectal examination reveals a uniformly enlarged, firm prostate without nodules. Serum PSA is 2.1 ng/mL. Transurethral resection of prostate (TURP) is performed for obstructive symptoms. Histologic examination of the resected tissue shows nodular hyperplasia with interspersed fibrous septa. Which tissue component is primarily responsible for the obstructive pathology in benign prostatic hyperplasia?
Answer choices
- AHyperplasia of acinar and ductal glandular epithelium with preserved columnar morphology
- BBenign adenocarcinoma arising from transition zone glands
- CNodular hyperplasia of smooth muscle and fibrous stromal tissueCorrect answer
- DSquamous metaplasia of the urethral mucosa with keratinization
- ELymphoid follicle formation with germinal centers compressing the urethra
- FHyaline cartilaginous metaplasia of the prostatic capsule
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