Histology USMLE Step 1 Practice Question
A 45-year-old woman undergoes a liver biopsy for suspected cirrhosis. Microscopic examination reveals extensive fibrosis with bridging between portal tracts and central veins, along with regenerative nodules of hepatocytes. The pathologist notes activation of hepatic stellate cells with increased collagen deposition in the space of Disse. Which of the following histological features best explains the mechanism of hepatic fibrosis in this patient?
Answer choices
- AIncreased synthesis of type IV collagen by portal tract bile duct epithelium
- BTransformation of hepatic stellate cells into myofibroblasts with increased type I and III collagen synthesisCorrect answer
- CProliferation of hepatocytes leading to compression of the sinusoidal endothelium
- DMetaplasia of hepatic sinusoidal endothelial cells into fibroblasts
- EAccumulation of lipid-laden Kupffer cells within the space of Disse
- FIncreased deposition of type II collagen by activated portal fibroblasts within the portal tracts
See the full explanation
Get the correct-answer rationale, why each distractor is wrong, the underlying mechanism, and high-yield associations — plus adaptive practice that targets your weak areas — with a free MedBoardPRO account.