Anemias USMLE Step 1 Practice Questions
57 board-style USMLE Step 1 questions in Hematology. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 · medium25. A 19 year old woman with sickle cell disease presents with pleuritic chest pain, fever, and shortness of breath 1 day after admission for a pain crisis. Pulse oximetry is 88 per…
- USMLE Step 1 · medium26. A 7-year-old boy with homozygous sickle cell disease presents with fever (39.2°C), lethargy, and malaise. Vital signs show HR 112/min, RR 24/min, BP 98/62 mmHg, and SpO2 98% on…
- USMLE Step 1 · easy27. A 16 year old African American boy presents with severe pain in both legs and shortness of breath after a viral illness. He has had recurrent painful episodes since childhood an…
- USMLE Step 1 · hard28. A 4-year-old boy presents with chronic hemolytic anemia, scleral icterus, and splenomegaly. Vital signs: HR 110/min, RR 22/min, BP 95/60 mmHg, temperature 37.2°C. Laboratory stu…
- USMLE Step 1 · medium29. A 23-year-old man with no prior medical history presents with jaundice, dark urine, and severe back pain 2 days after starting trimethoprim-sulfamethoxazole for cellulitis. Vita…
- USMLE Step 1 · medium30. A 15 year old boy is brought for recurrent jaundice and fatigue. He has had multiple episodes of pigmented gallstones, and his mother had a splenectomy at age 20. Examination sh…
- USMLE Step 1 · easy31. A 6 year old boy is brought for abdominal pain, constipation, and declining school performance. His family recently moved into an older home undergoing renovation. Physical exam…
- USMLE Step 1 · medium32. A 24 year old Southeast Asian woman is noted to have persistent microcytosis on routine laboratory testing during pregnancy. She feels well and denies bleeding. Hemoglobin is 11…
- USMLE Step 1 · medium33. A 9 month old boy of Mediterranean ancestry is brought for poor feeding and failure to thrive. Examination shows pallor, jaundice, and frontal bossing. Laboratory studies reveal…
- USMLE Step 1 · medium34. A 44 year old man with alcohol use disorder presents with fatigue and numbness in his feet. He has recently been treated for tuberculosis. Laboratory studies show hemoglobin 9.7…
- USMLE Step 1 · medium35. A 58 year old woman with long standing rheumatoid arthritis presents with worsening fatigue. She has morning stiffness involving both hands and elevated inflammatory markers. La…
- USMLE Step 1 · easy36. A 67 year old man is evaluated for progressive fatigue and exertional dyspnea for 4 months. He also reports craving ice and has had a 5 kg unintentional weight loss. Physical ex…
- USMLE Step 1 · medium37. A 4-year-old boy presents with a 3-week history of abdominal pain, constipation, and irritability. His family recently moved into an old home undergoing renovation. Vital signs…
- USMLE Step 1 · hard38. A 34-year-old man presents with episodic dark urine in the morning and abdominal pain. He has a history of a hepatic vein thrombosis. Laboratory studies show hemolytic anemia wi…
- USMLE Step 1 · medium39. A 63-year-old woman presents with progressive fatigue, glossitis, and paresthesias in both hands. Vital signs: BP 128/76, HR 92, RR 18, Temp 37°C, SpO2 98% on room air. Laborato…
- USMLE Step 1 · easy40. A 31-year-old pregnant woman at 24 weeks gestation presents with progressive fatigue and dyspnea on exertion. Vital signs: BP 118/76, HR 98, RR 18, Temp 37°C, SpO2 98%. She has…
- USMLE Step 1 · easy41. A 68-year-old man comes to the physician because of fatigue and difficulty walking. He reports numbness in both feet. Examination shows decreased vibration sense in the lower ex…
- USMLE Step 1 · easy42. A 25-year-old woman comes to the emergency department because of fatigue, recurrent nosebleeds, and fevers. She recently completed chloramphenicol therapy abroad. Laboratory stu…
- USMLE Step 1 · medium43. A 5-year-old girl is brought to the hospital because of decreased urine output and pallor. Three days earlier she developed bloody diarrhea after eating undercooked ground beef…
- USMLE Step 1 · medium44. A 31-year-old woman is brought to the emergency department because of confusion and severe fatigue. She has petechiae on her legs. Laboratory studies show hemoglobin 8.1 g/dL, p…
- USMLE Step 1 · medium45. A 67-year-old man comes to the office in winter because of fatigue and dark urine. He reports that his fingers become painful and bluish when he walks outside in the cold. Labor…
- USMLE Step 1 · medium46. A 34-year-old woman with systemic lupus erythematosus comes to the clinic because of fatigue and jaundice. Examination shows mild splenomegaly. Laboratory studies reveal anemia,…
- USMLE Step 1 · medium47. An 11-year-old boy with sickle cell disease is brought to the emergency department because of profound fatigue and lightheadedness for 2 days. He had a low-grade fever and a mil…
- USMLE Step 1 · medium48. A 24-year-old man is evaluated for painless gross hematuria after strenuous exercise. He has no dysuria or flank pain. He is otherwise healthy, and urinalysis shows many red blo…