Anemias USMLE Step 1 Practice Question
A 5-year-old girl is brought to the hospital because of decreased urine output and pallor. Three days earlier she developed bloody diarrhea after eating undercooked ground beef at a picnic. Laboratory studies show anemia, thrombocytopenia, elevated creatinine, and schistocytes on peripheral smear. PT and PTT are normal. Which of the following is the most likely cause of her condition?
Answer choices
- AShiga-like toxin causing endothelial injuryCorrect answer
- BDeficiency of vitamin K
- CLoss of CD55 and CD59 on hematopoietic cells
- DDeficiency of ADAMTS13
- EAutoantibodies against factor VIII
- FDeficiency of von Willebrand factor
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