Adrenal Disorders USMLE Step 1 Practice Questions
56 board-style USMLE Step 1 questions in Endocrinology. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 · hard1. A 35-year-old woman presents to clinic with a 6-month history of progressive hypertension, central weight gain, and easy bruising. She denies exogenous corticosteroid use. Vital…
- USMLE Step 1 · hard2. A 21-year-old woman presents with a 2-year history of progressive facial hirsutism, acne, and irregular menses occurring every 45-65 days. She denies medication use and reports…
- USMLE Step 1 · medium3. A 42-year-old woman presents with progressive muscle weakness, hypokalemia (K+ 2.8 mEq/L), and hypertension over 6 months. Laboratory studies reveal metabolic alkalosis, suppres…
- USMLE Step 1 · easy4. A 52-year-old man with hypertension controlled on a single antihypertensive agent presents for a routine CT abdomen for evaluation of flank pain. Imaging reveals a 2.3-cm left a…
- USMLE Step 1 · hard5. A 63-year-old woman with a history of lung cancer presents with sudden onset severe back pain, hypotension (BP 85/50 mmHg), and altered mental status. She is found to have Na+ 1…
- USMLE Step 1 · medium6. A 19-year-old girl presents with primary amenorrhea, clitoromegaly, and short stature. Vital signs show BP 92/58 mmHg, HR 108 bpm, RR 22/min, and temperature 37.2°C. Laboratory…
- USMLE Step 1 · hard7. A 41-year-old man with a 10-year history of hypertension presents to clinic for routine follow-up. On examination, blood pressure is 158/96 mmHg. Laboratory studies show serum p…
- USMLE Step 1 · easy8. A 28-year-old man presents with progressive fatigue, weakness, and weight loss over 3 months. On examination, he has diffuse hyperpigmentation and appears cachectic. Vital signs…
- USMLE Step 1 · medium9. A 34-year-old woman with no prior medical history presents to clinic with fatigue and muscle weakness. She was found to be hypertensive (BP 162/98 mmHg) during a routine visit.…
- USMLE Step 1 · hard10. A 52-year-old man with a 10-year history of hypertension presents to the emergency department with a 2-hour history of sudden-onset severe occipital headache, diaphoresis, and t…
- USMLE Step 1 · medium11. A 38-year-old man with confirmed Cushing syndrome undergoes high-dose dexamethasone suppression testing. His 24-hour urinary free cortisol decreases from 350 µg/24h to 85 µg/24h…
- USMLE Step 1 · easy12. A 45-year-old woman presents with progressive proximal muscle weakness, easy bruising, and facial plethora. Her BP is 165/95 mmHg. Laboratory studies show hypokalemia and metabo…
- USMLE Step 1 · medium13. A 32-year-old man with a history of multiple endocrine neoplasia type 1 (MEN-1) presents to the emergency department with a 2-month history of episodic severe headaches, profuse…
- USMLE Step 1 · hard14. A 50-year-old man with a history of hypertension presents to the emergency department with sudden-onset severe left flank pain radiating to the left groin, nausea, and diaphores…
- USMLE Step 1 · medium15. A 28-year-old woman on long-term prednisone for systemic lupus erythematosus presents with progressive fatigue, weakness, and orthostatic hypotension during glucocorticoid taper…
- USMLE Step 1 · hard16. A 58-year-old man with a 2-pack-per-day smoking history presents with profound muscle weakness, hypertension, and marked hypokalemia (K+ 2.8 mEq/L). His cortisol is 28 μg/dL and…
- USMLE Step 1 · medium17. A 42-year-old woman presents to the endocrinology clinic with a 6-month history of progressive facial plethora, easy bruising, proximal leg weakness, and irritability. Her blood…
- USMLE Step 1 · easy18. A 38-year-old previously healthy man presents to the emergency department with acute onset severe abdominal pain, nausea, and altered mental status. His wife reports he has been…
- USMLE Step 1 · medium19. A 45-year-old woman presents to her primary care physician for evaluation of newly detected hypertension. Her blood pressure is 158/96 mmHg. She reports mild fatigue and ankle s…
- USMLE Step 1 · medium20. A 52-year-old man with a history of tuberculosis presents with fatigue and weight loss. His morning cortisol is 2 μg/dL and ACTH is 180 pg/mL. He does not have skin hyperpigment…
- USMLE Step 1 · easy21. A 35-year-old woman presents with progressive fatigue, weakness, and diffuse skin hyperpigmentation. Vital signs show hypotension (90/55 mmHg), heart rate 102 bpm, and temperatu…
- USMLE Step 1 · hard22. A 3-year-old girl with congenital adrenal hyperplasia due to 21-hydroxylase deficiency presents to the emergency department with lethargy, vomiting, and poor perfusion. Her pare…
- USMLE Step 1 · medium23. A 48-year-old woman with a 10-year history of hypertension, diabetes mellitus, and obesity presents with severe fatigue and bruising. Laboratory studies show cortisol 28 µg/dL,…
- USMLE Step 1 · medium24. A 55-year-old man presents to his primary care physician with a 6-month history of progressive proximal muscle weakness, easy bruising, and worsening hypertension despite being…