Adrenal Disorders USMLE Step 1 Practice Question
A 19-year-old girl presents with primary amenorrhea, clitoromegaly, and short stature. Vital signs show BP 92/58 mmHg, HR 108 bpm, RR 22/min, and temperature 37.2°C. Laboratory studies reveal 17-hydroxyprogesterone 8 ng/mL (normal <2 ng/mL), sodium 130 mEq/L, elevated plasma renin activity, and normal cortisol levels. She denies recent medication use. Which of the following is the most likely diagnosis?
Answer choices
- A11β-hydroxylase deficiency
- B21-hydroxylase deficiency (classic salt-wasting form)Correct answer
- CAndrogen insensitivity syndrome
- D3β-hydroxysteroid dehydrogenase deficiency
- E17α-hydroxylase deficiency
- FLipoid congenital adrenal hyperplasia (lipoid CAH)
See the full explanation
Get the correct-answer rationale, why each distractor is wrong, the underlying mechanism, and high-yield associations — plus adaptive practice that targets your weak areas — with a free MedBoardPRO account.