Thyroid Disorders USMLE Step 1 Practice Questions
54 board-style USMLE Step 1 questions in Endocrinology. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 · medium25. A 35-year-old woman on levothyroxine 75 mcg daily for hypothyroidism reports persistent fatigue and myalgias despite a normal TSH of 2.1 mIU/L 6 weeks ago. She takes her medicat…
- USMLE Step 1 · medium26. A 28-year-old woman presents with a 6-month history of amenorrhea, tremor, heat intolerance, and palpitations. On examination, her thyroid is diffusely enlarged and nontender. V…
- USMLE Step 1 · easy27. A 42-year-old woman presents with progressive fatigue, weight gain, cold intolerance, and constipation over three months. Vital signs show HR 52 bpm, BP 138/88 mmHg, temperature…
- USMLE Step 1 · hard28. A 70-year-old man is admitted to the ICU with severe sepsis secondary to pneumonia. Vital signs show BP 92/58, HR 118, RR 28, temp 39.2°C, SpO2 88%. Thyroid function tests revea…
- USMLE Step 1 · hard29. A 10-year-old boy presents with short stature, round facies, and shortened fourth and fifth metacarpals. Vital signs show BP 102/68 mmHg, HR 78/min, RR 18/min, temperature 37°C.…
- USMLE Step 1 · medium30. A 63-year-old man with stage 4 chronic kidney disease presents with progressive diffuse bone pain and muscle weakness. Vital signs: BP 148/92 mmHg, HR 88/min, RR 16/min, temp 37…
- USMLE Step 1 · medium31. A 56-year-old woman presents with constipation, depressed mood, and a history of recurrent kidney stones. Vital signs: BP 138/88 mmHg, HR 58 bpm, RR 14, Temp 36.8°C, SpO2 98%. L…
- USMLE Step 1 · medium32. A 41-year-old man presents with a 3-month history of chronic watery diarrhea and is found to have a thyroid nodule on examination. Vital signs show BP 148/92 mmHg, HR 102 bpm, R…
- USMLE Step 1 · hard33. A 23-year-old woman began oral contraceptive pills 6 weeks ago. She reports palpitations and mild heat intolerance but denies weight loss or neck pain. Vital signs show HR 92 bp…
- USMLE Step 1 · medium34. A 34 year old woman develops anterior neck pain radiating to the jaw several weeks after an upper respiratory infection. She has palpitations and mild fever. The thyroid gland i…
- USMLE Step 1 · easy35. A 45-year-old woman presents with progressive fatigue, weight gain of 8 kg over 3 months, constipation, and cold intolerance. Vital signs show BP 128/82 mmHg, HR 58 bpm, RR 14/m…
- USMLE Step 1 · medium36. A 28-year-old woman presents with progressive weight loss despite increased appetite, heat intolerance, anxiety, and palpitations for 6 weeks. Vital signs show BP 148/82 mmHg, H…
- USMLE Step 1 · medium37. A 35-year-old woman presents with palpitations, heat intolerance, and tremor for 3 months. Vital signs show HR 105 bpm, BP 138/72 mmHg, RR 18/min, temp 37.2°C. She denies recent…
- USMLE Step 1 · medium38. A 55-year-old woman with hypothyroidism on levothyroxine 75 mcg daily presents with persistent fatigue and weight gain. Vital signs: BP 128/82, HR 58, RR 14, Temp 36.8°C. TSH is…
- USMLE Step 1 · hard39. A 34-year-old woman with untreated Graves disease is brought to the emergency department with fever, agitation, vomiting, and palpitations 1 day after emergency abdominal surger…
- USMLE Step 1 · medium40. A 36-year-old woman with Graves disease started on methimazole 3 weeks ago presents with fever (38.9°C), severe pharyngitis, and cervical lymphadenopathy. Vital signs show HR 10…
- USMLE Step 1 · medium41. A 27-year-old woman at 8 weeks gestation presents with palpitations, heat intolerance, and weight loss despite increased appetite. Vital signs show HR 108 bpm, BP 138/82 mmHg, R…
- USMLE Step 1 · medium42. A 49-year-old woman presents with perioral numbness and carpopedal spasm 2 days following total thyroidectomy. Vital signs show BP 128/82, HR 88, RR 16, temperature 37.2°C. Phys…
- USMLE Step 1 · hard43. A 12-year-old boy presents with muscle cramps, paresthesias, and a history of developmental delay. Vital signs: BP 118/76 mmHg, HR 88 bpm, RR 16/min, Temp 37°C, SpO2 98% on room…
- USMLE Step 1 · easy44. A 56-year-old woman presents with recurrent nephrolithiasis and progressive diffuse bone pain. Vital signs: BP 138/82 mmHg, HR 88/min, RR 14/min, temperature 37.2°C. Laboratory…
- USMLE Step 1 · hard45. A 78-year-old woman presents with a 2-month history of rapidly enlarging neck mass, progressive dysphagia, and hoarseness. Vital signs show BP 138/82, HR 92, RR 18, temp 37.2°C,…
- USMLE Step 1 · medium46. A 40-year-old woman presents with a thyroid nodule discovered on ultrasound. Vital signs are stable (BP 128/82, HR 78, RR 16, Temp 37°C). Laboratory studies reveal elevated calc…
- USMLE Step 1 · medium47. A 52-year-old woman from a region with longstanding dietary iodine deficiency presents with a solitary thyroid nodule. Vital signs are stable (BP 128/82, HR 78, RR 16, Temp 37°C…
- USMLE Step 1 · medium48. A 33-year-old woman with a history of therapeutic neck radiation in childhood presents with a painless thyroid nodule. Vital signs are stable: BP 118/76, HR 82, RR 16, Temp 37°C…