Thyroid Disorders USMLE Step 1 Practice Question
A 36-year-old woman with Graves disease started on methimazole 3 weeks ago presents with fever (38.9°C), severe pharyngitis, and cervical lymphadenopathy. Vital signs show HR 102/min, BP 118/76 mmHg, RR 18/min, SpO2 98% on room air. Laboratory studies reveal WBC 1.8 × 10³/μL with neutropenia. She denies rash or joint pain. Which of the following is the most likely explanation for her acute presentation?
Answer choices
- APheochromocytoma
- BAdrenal crisis
- CCentral hypothyroidism
- DAgranulocytosisCorrect answer
- EThyroid storm
- FAntithyroid drug-induced hepatotoxicity
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