Thyroid Disorders USMLE Step 1 Practice Questions
54 board-style USMLE Step 1 questions in Endocrinology. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 · hard1. A 45-year-old woman with Hashimoto thyroiditis on levothyroxine 100 mcg daily presents with recurrent symptoms of fatigue and cognitive impairment despite a TSH of 1.5 mIU/L (wi…
- USMLE Step 1 · medium2. A 28-year-old woman at 8 weeks gestation presents for prenatal care. Her TSH is 6.2 mIU/L and free T4 is 0.9 ng/dL (low end of normal). She reports no symptoms. Thyroid peroxida…
- USMLE Step 1 · easy3. A 52-year-old man presents to his primary care physician with a 3-month history of progressive fatigue, weight gain of 8 kg, and cold intolerance. He denies palpitations, anxiet…
- USMLE Step 1 · medium4. A 34-year-old woman presents with palpitations, heat intolerance, and a 4-kg weight loss over 2 months. She has a diffuse thyroid enlargement without tenderness. Laboratory stud…
- USMLE Step 1 · hard5. A 44-year-old woman presents to clinic with a 6-month history of progressive fatigue, difficulty concentrating, and cold intolerance. She reports a 3-kg weight gain despite no c…
- USMLE Step 1 · hard6. A 19-year-old woman with recent viral infection presents with fatigue, weight loss despite increased appetite, palpitations, and anxiety. Examination reveals tremor, warm skin,…
- USMLE Step 1 · medium7. A 31-year-old woman presents with sudden-onset severe neck pain, fever (38.9°C), and malaise. Vital signs show tachycardia (HR 102/min) and tachypnea (RR 20/min). Laboratory stu…
- USMLE Step 1 · medium8. A 52-year-old man presents to the emergency department with a 2-week history of profuse watery diarrhea (8-10 bowel movements daily) and recurrent episodes of facial flushing an…
- USMLE Step 1 · medium9. A 35-year-old woman at 12 weeks gestation presents with thyroid eye disease, tremor, and palpitations. Vital signs show HR 102 bpm, BP 138/88 mmHg, RR 18, temp 37.2°C. Labs reve…
- USMLE Step 1 · easy10. A 42-year-old woman presents with a 3-month history of fatigue, weight gain, cold intolerance, and constipation. Vital signs show HR 52 bpm, BP 128/82 mmHg, temperature 36.2°C.…
- USMLE Step 1 · hard11. A 38-year-old woman with untreated Graves disease presents with high fever (40.2°C), severe tachycardia (HR 158), altered mental status, and tremor. She admits to stopping her a…
- USMLE Step 1 · easy12. A 32-year-old woman presents 3 months postpartum with fatigue, depression, and palpitations. Vital signs show HR 92 bpm, BP 128/82 mmHg, RR 16, temperature 37.2°C. TSH is elevat…
- USMLE Step 1 · medium13. A 68-year-old man with chronic atrial fibrillation on warfarin presents with fatigue, weight loss, and heat intolerance. TSH is suppressed at 0.08 mIU/L and free T4 is elevated…
- USMLE Step 1 · medium14. A 40-year-old woman with no significant past medical history presents for evaluation of a thyroid nodule found incidentally on ultrasound performed for neck pain. She denies con…
- USMLE Step 1 · medium15. A 62-year-old man with newly diagnosed hypothyroidism started levothyroxine 50 mcg daily. Six weeks later, he presents with palpitations and irregular heartbeat. Vital signs sho…
- USMLE Step 1 · medium16. A 45-year-old woman presents with acute onset neck pain, fever, and mild hyperthyroid symptoms. Examination reveals a tender thyroid gland. TSH is 0.1 mIU/L, free T4 is elevated…
- USMLE Step 1 · medium17. A 28-year-old woman at 8 weeks gestation presents for prenatal screening. Her TSH is 0.2 mIU/L (normal pregnancy range: 0.1–2.5) and free T4 is normal. She has no symptoms of th…
- USMLE Step 1 · easy18. A 35-year-old woman presents with a 2-month history of heat intolerance, palpitations, and a 4 kg unintentional weight loss despite increased appetite. On examination, she has a…
- USMLE Step 1 · medium19. A 67-year-old woman presents to clinic with a 3-month history of fatigue, weight gain, constipation, and cold intolerance. Her past medical history is significant for atrial fib…
- USMLE Step 1 · hard20. A 58-year-old man with a history of papillary thyroid cancer treated with total thyroidectomy 5 years ago is on levothyroxine suppression therapy. His current free T4 is 1.9 ng/…
- USMLE Step 1 · medium21. A 6-year-old girl is brought to the clinic by her parents who report that she has not grown well since infancy despite adequate nutrition. On examination, she is at the 3rd perc…
- USMLE Step 1 · medium22. A 51-year-old woman presents with a 2-week history of severe anxiety, palpitations, and tremor. She was started on amiodarone for atrial fibrillation 2 weeks ago. Vital signs sh…
- USMLE Step 1 · hard23. A 29-year-old woman at 14 weeks gestation presents for prenatal care. She reports a 3-week history of palpitations, anxiety, and heat intolerance. Vital signs show heart rate 10…
- USMLE Step 1 · hard24. A 54-year-old man presents to clinic with progressive fatigue, weight gain, and decreased libido over the past 6 months. He has a history of Hodgkin lymphoma treated with medias…