Thyroid Disorders USMLE Step 1 Practice Question
A 35-year-old woman presents with palpitations, heat intolerance, and tremor for 3 months. Vital signs show HR 105 bpm, BP 138/72 mmHg, RR 18/min, temp 37.2°C. She denies recent neck pain or radioactive iodine exposure. Laboratory studies reveal suppressed TSH at 0.05 mIU/L and elevated free T4 at 2.8 ng/dL. A researcher identifies immunoglobulins that activate adenylate cyclase in thyroid follicular cells, driving excess thyroid hormone production. Which condition is most strongly associated with these antibodies?
Answer choices
- ASecondary hypothyroidism
- BHashimoto thyroiditis
- CGraves diseaseCorrect answer
- DSubacute thyroiditis
- EMedullary thyroid carcinoma
- FToxic thyroid adenoma with autonomously functioning nodule
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