Neuromuscular Disorders USMLE Step 1 Practice Questions
64 board-style USMLE Step 1 questions in Neurology. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 · medium1. A 6-year-old boy is brought to the emergency department by his parents after he fell while playing soccer and was unable to get up. He has a 10-month history of progressive diff…
- USMLE Step 1 · hard2. A 24-year-old man presents with recurrent episodes of transient focal weakness following minor compression injuries, including wrist drop after sleeping on his arm and foot drop…
- USMLE Step 1 · medium3. A 57-year-old man with progressive neuromuscular weakness presents with morning headaches and orthopnea. Vital signs show BP 145/92, HR 88, RR 22, temperature 37.2°C, SpO2 98% o…
- USMLE Step 1 · medium4. An 8-year-old unvaccinated boy presents with fever (38.9°C), sore throat, and progressive asymmetric flaccid paralysis of the left leg over 3 days. Vital signs show HR 102 bpm,…
- USMLE Step 1 · hard5. A 36-year-old woman with myasthenia gravis self-increased her pyridostigmine dose without medical supervision. She presents with generalized weakness, diarrhea, diaphoresis, and…
- USMLE Step 1 · hard6. A 42-year-old woman with myasthenia gravis and a recent upper respiratory infection presents with worsening dysphagia, nasal speech, and dyspnea. Vital signs show BP 128/82, HR…
- USMLE Step 1 · medium7. A 38-year-old man with chronic spinal cord injury presents with painful lower extremity spasms and increased muscle tone disrupting sleep. Vital signs: BP 128/82, HR 78, RR 16,…
- USMLE Step 1 · medium8. A 19-year-old man develops muscle rigidity and high fever shortly after induction of general anesthesia with sevoflurane and succinylcholine. Vital signs show temperature 39.2°C…
- USMLE Step 1 · medium9. A 35-year-old woman presents with fatigable ptosis and diplopia. Vital signs: BP 118/76, HR 88, RR 16, Temp 37°C, SpO2 98%. She reports symptoms worsen with activity and improve…
- USMLE Step 1 · hard10. A 23-year-old woman presents to the emergency department with severe colicky abdominal pain, anxiety, and acute proximal arm and leg weakness. Vital signs show BP 148/92 mmHg, H…
- USMLE Step 1 · medium11. A 46-year-old battery factory worker presents with acute wrist drop and foot drop. He reports abdominal pain, irritability, and constipation for 3 weeks. Vital signs: BP 148/92,…
- USMLE Step 1 · hard12. A 12-year-old unvaccinated boy presents with sore throat and a gray pharyngeal membrane. Three weeks after symptom onset, he develops palatal weakness and distal paresthesias. V…
- USMLE Step 1 · hard13. A 7-year-old girl develops progressive ascending weakness over 2 days while camping in the summer. Reflexes are decreased. She is afebrile, and CSF protein is normal. Careful sk…
- USMLE Step 1 · hard14. A 26-year-old man presents with severe diffuse myalgias, abdominal cramping, and diaphoresis after sustaining a spider bite while cleaning a garage. Vital signs show BP 158/94 m…
- USMLE Step 1 · medium15. A 29-year-old male farm worker is brought to the emergency department 30 minutes after acute pesticide exposure. He presents with diaphoresis, excessive salivation, abdominal cr…
- USMLE Step 1 · medium16. A 55-year-old woman with severe asthma on high-dose prednisone (60 mg daily) for 6 months presents with progressive difficulty rising from chairs and climbing stairs. Vital sign…
- USMLE Step 1 · medium17. A 67-year-old man initiated high-intensity atorvastatin therapy 3 weeks ago following myocardial infarction. He now presents with diffuse myalgias and proximal lower extremity w…
- USMLE Step 1 · medium18. A 3-month-old male infant presents with poor feeding and generalized hypotonia for 2 weeks. Vital signs show HR 145/min, RR 32/min, BP 78/52 mmHg, and normal temperature. Physic…
- USMLE Step 1 · medium19. A 17-year-old boy presents with severe muscle cramps and dark urine following intense basketball practice. Vital signs show BP 118/76, HR 102, RR 18, temp 37.2°C, SpO2 98%. Seru…
- USMLE Step 1 · hard20. A 22-year-old man presents with recurrent episodes of generalized weakness beginning after rest following strenuous exercise. Episodes last 20-45 minutes and are associated with…
- USMLE Step 1 · hard21. A 19-year-old man presents with recurrent episodes of flaccid proximal weakness beginning after strenuous exercise or large carbohydrate meals. Between episodes he is neurologic…
- USMLE Step 1 · medium22. A 61-year-old woman presents with brief episodes of excruciating electric shock-like pain over the right cheek and jaw triggered by brushing her teeth and chewing. Vital signs:…
- USMLE Step 1 · easy23. A 34-year-old woman presents with acute-onset right facial weakness over 24 hours. Vital signs: BP 118/76, HR 82, RR 14, temp 37.2°C, SpO2 98% on room air. She cannot close her…
- USMLE Step 1 · medium24. A 39-year-old male cyclist presents with numbness of the little finger and medial half of the ring finger following a 6-hour race. Vital signs are stable (BP 128/76, HR 82, RR 1…