Fungal and Parasitic Infections USMLE Step 1 Practice Questions
55 board-style USMLE Step 1 questions in Infectious Disease. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 · medium1. A 27-year-old man with AIDS is brought to the hospital 30 minutes after having a seizure. He currently takes no medications. His temperature is 38.2°C, blood pressure is 128/78…
- USMLE Step 1 · easy2. A 28-year-old woman with no past medical history presents with severe frontal headache, photophobia, and fever lasting 2 weeks. CSF analysis shows elevated protein, low glucose,…
- USMLE Step 1 · medium3. A 45-year-old man from the Southwest presents with fever, cough, and erythema nodosum. Chest X-ray shows hilar lymphadenopathy and a cavitary lesion in the left upper lobe. Sput…
- USMLE Step 1 · medium4. A 32-year-old woman presents with progressive dyspnea, fever, and bilateral interstitial infiltrates on chest X-ray. She is HIV-positive with a CD4 count of 45 cells/μL and has…
- USMLE Step 1 · easy5. A 6-year-old girl from sub-Saharan Africa presents with her mother reporting a 3-week history of chronic diarrhea, abdominal pain, and progressive abdominal distension. The moth…
- USMLE Step 1 · hard6. A 58-year-old man with type 2 diabetes mellitus (HbA1c 10.2%) presents to the emergency department with a 5-day history of rapidly progressive foot pain and tissue necrosis. He…
- USMLE Step 1 · hard7. A 42-year-old woman with systemic lupus erythematosus on chronic corticosteroid therapy presents to the emergency department with a 2-week history of progressive headache, low-g…
- USMLE Step 1 · easy8. A 55-year-old man with HIV presents to the emergency department with a 5-day history of dysphagia, odynophagia, and fever. He reports oral thrush that began 2 weeks ago. Medical…
- USMLE Step 1 · hard9. A 35-year-old immunocompetent man presents with a painless nodule on his forearm that expanded over 6 months with central ulceration and lymphangitis. He is a gardener in a subt…
- USMLE Step 1 · medium10. A 5-year-old girl from a malaria-endemic region presents with fever (38.9°C), hepatosplenomegaly, and pallor. She received inconsistent antimalarial prophylaxis. Vital signs sho…
- USMLE Step 1 · medium11. A 67-year-old man with chronic lung disease presents with progressive dyspnea and fever. High-resolution CT shows upper lobe nodules with cavitation. He has a 20-pack-year smoki…
- USMLE Step 1 · medium12. A 42-year-old woman from Arizona presents with a 3-month history of progressive cough, hemoptysis, and night sweats. She denies dyspnea at rest but reports fatigue. Vital signs:…
- USMLE Step 1 · easy13. A 34-year-old man with HIV infection presents to the emergency department with a 2-week history of fever, progressive headache, and neck stiffness. He has not taken antiretrovir…
- USMLE Step 1 · hard14. A 28-year-old woman with systemic lupus erythematosus on chronic corticosteroid therapy presents to the emergency department with a 2-week history of progressive headache, low-g…
- USMLE Step 1 · hard15. A 56-year-old man with type 2 diabetes mellitus presents to the emergency department with a 3-day history of severe facial pain, right-sided nasal congestion, and fever. On exam…
- USMLE Step 1 · medium16. A 42-year-old woman from Ohio presents to dermatology with a 6-month history of a slowly enlarging, painless nodular lesion on her forearm. She reports frequent exposure to soil…
- USMLE Step 1 · easy17. A 35-year-old woman returns from a 3-week mission trip to Sub-Saharan Africa with progressive pruritic, scaling rash on her hands and feet. Vital signs: BP 118/76, HR 88, RR 16,…
- USMLE Step 1 · medium18. A 45-year-old man with untreated HIV (CD4 20 cells/μL) presents with fever (39.2°C), headache, and confusion for 2 weeks. Vital signs show BP 108/70, HR 98, RR 16, SpO2 98%. CSF…
- USMLE Step 1 · hard19. A 28-year-old man from Brazil presents with oral lesions, difficulty swallowing, and lymphadenopathy. Examination shows painful nodules and ulcers on his lip. He works as a farm…
- USMLE Step 1 · hard20. A 45-year-old woman with poorly controlled diabetes (HbA1c 11.2%) presents with severe frontal headache, proptosis, and black necrotic tissue involving the nasal turbinate and p…
- USMLE Step 1 · medium21. A 32-year-old woman with systemic lupus erythematosus presents to the hospital with a 2-week history of progressive dyspnea, nonproductive cough, and low-grade fever. She has be…
- USMLE Step 1 · hard22. A 62-year-old neutropenic man undergoing chemotherapy for acute leukemia presents with fever (38.9°C), tachycardia (110 bpm), and dyspnea unresponsive to broad-spectrum antibiot…
- USMLE Step 1 · medium23. A 28-year-old man with a history of pulmonary tuberculosis treated 3 years ago presents to the emergency department with a 3-week history of progressive hemoptysis, low-grade fe…
- USMLE Step 1 · medium24. A 42-year-old man with HIV/AIDS (CD4 count 45 cells/μL) presents with severe headache, fever (39.2°C), and altered mental status. Vital signs show BP 118/76 mmHg, HR 102 bpm, RR…