Fungal and Parasitic Infections USMLE Step 1 Practice Question
A 42-year-old man with HIV/AIDS (CD4 count 45 cells/μL) presents with severe headache, fever (39.2°C), and altered mental status. Vital signs show BP 118/76 mmHg, HR 102 bpm, RR 20/min, SpO2 98% on room air. Lumbar puncture reveals opening pressure 35 cm H₂O, CSF glucose 28 mg/dL, protein 156 mg/dL, and positive India ink stain. No focal neurologic deficits are noted. Which of the following is the most appropriate initial treatment?
Answer choices
- AAmphotericin B plus flucytosineCorrect answer
- BTerbinafine plus posaconazole
- CMicafungin monotherapy
- DItraconazole plus voriconazole
- EFluconazole monotherapy
- FCaspofungin plus anidulafungin
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