Metabolism USMLE Step 1 Practice Questions
110 board-style USMLE Step 1 questions in Biochemistry. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 · medium25. A 23-year-old woman presents with severe colicky abdominal pain, anxiety, and dark reddish urine three days after initiating phenobarbital for insomnia. Vital signs show HR 118/…
- USMLE Step 1 · medium26. A 3 year old boy is brought to the clinic because of abdominal pain, constipation, and decreased energy. His family recently moved into an older home that is undergoing renovati…
- USMLE Step 1 · medium27. A 7-year-old boy with cystic fibrosis and chronic steatorrhea presents with progressive balance difficulty and decreased vibration sense in his lower extremities. Vitals: BP 105…
- USMLE Step 1 · easy28. A 4 year old boy recently immigrated from a resource limited region is brought to clinic for difficulty seeing at night. His mother says he frequently bumps into furniture when…
- USMLE Step 1 · medium29. A 29 year old woman with severe rheumatoid arthritis develops fatigue and oral ulcers 2 months after starting a new medication. Laboratory studies show hemoglobin 9.8 g/dL, MCV…
- USMLE Step 1 · medium30. A 63 year old woman presents with fatigue, numbness in her feet, and difficulty walking. Examination shows decreased vibration sense in both legs and a smooth beefy red tongue.…
- USMLE Step 1 · easy31. A 6 year old boy is brought to clinic because of fatigue, gum bleeding, and pain in both legs. His family recently experienced food insecurity, and his diet has consisted mainly…
- USMLE Step 1 · medium32. A 27 year old woman is evaluated for diffuse hair loss and a scaly dermatitis around the eyes, nose, and mouth. She recently completed a prolonged course of broad spectrum antib…
- USMLE Step 1 · medium33. A 52 year old woman with metastatic renal cell carcinoma enrolls in a trial of a drug that irreversibly binds an allosteric site on a signaling enzyme and reduces its catalytic…
- USMLE Step 1 · easy34. A 34 year old man is brought to the emergency department 8 hours after ingesting windshield washer fluid during a suicide attempt. He complains of blurry vision and abdominal pa…
- USMLE Step 1 · hard35. A 7-month-old boy presents with failure to thrive and pallor. Vital signs show HR 128/min, RR 22/min, Temp 37.2°C. Laboratory studies reveal hemoglobin 7.2 g/dL with megaloblast…
- USMLE Step 1 · medium36. A 4-month-old male presents with recurrent oral thrush, chronic diarrhea, and recurrent severe respiratory infections. Vital signs show HR 128/min, RR 32/min, temperature 37.2°C…
- USMLE Step 1 · easy37. A 3 year old boy is brought in for developmental delay and involuntary writhing movements. He has a history of self mutilation with biting of his lips and fingers. Orange sand l…
- USMLE Step 1 · easy38. A 23 year old man develops jaundice and dark urine 2 days after starting trimethoprim sulfamethoxazole for a skin infection. He had a similar episode after eating fava beans. La…
- USMLE Step 1 · hard39. A 7-month-old infant presents with extreme irritability, developmental regression, and feeding difficulty over the past 6 weeks. Vital signs show HR 128/min, RR 26/min, temp 37.…
- USMLE Step 1 · hard40. A 4-year-old girl presents with progressive gait instability and loss of speech over 6 months. Vital signs show BP 98/62, HR 102, RR 22, temp 37.2°C, SpO2 98%. Neurologic examin…
- USMLE Step 1 · medium41. A 7-year-old boy presents with progressive developmental delay, aggressive behavior, and coarse facial features. Vital signs show BP 95/60, HR 102, RR 22, Temp 37.2°C, SpO2 98%…
- USMLE Step 1 · medium42. A 3-year-old boy presents with developmental delay and recurrent upper airway infections. Vital signs show HR 110/min, RR 28/min, BP 105/65 mmHg, temperature 37.2°C. Physical ex…
- USMLE Step 1 · medium43. A 24-year-old man presents with progressive burning pain in his hands and feet worsening with exercise. Vital signs show BP 138/88, HR 98, RR 16, temp 37°C, SpO2 98%. He has clu…
- USMLE Step 1 · medium44. A 13-year-old boy presents with progressive fatigue, easy bruising, and recurrent bone pain over 6 months. Vital signs show BP 105/68, HR 92, RR 18, temp 37.2°C, SpO2 98%. Exami…
- USMLE Step 1 · medium45. A 1-year-old girl presents with developmental regression, abdominal distention, and failure to thrive. Vital signs show HR 110/min, RR 28/min, temp 37.2°C. Physical examination…
- USMLE Step 1 · easy46. A 10-month-old boy presents with progressive developmental regression and an exaggerated startle response over the past 2 months. Vital signs: HR 118/min, RR 28/min, Temp 37.2°C…
- USMLE Step 1 · medium47. A 2-week-old boy presents with poor feeding and lethargy. Vital signs show HR 145 bpm, RR 32/min, BP 68/42 mmHg, temperature 37.2°C. Laboratory studies reveal high anion gap met…
- USMLE Step 1 · medium48. A 4-day-old female newborn presents with poor feeding, vomiting, hypotonia, and seizures. Vital signs reveal HR 155 bpm, RR 28/min, temp 37.2°C. Laboratory studies demonstrate h…