Metabolism USMLE Step 1 Practice Questions
110 board-style USMLE Step 1 questions in Biochemistry. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 · hard1. A 9-year-old girl is brought to the emergency department for sudden-onset slurring of speech and weakness of her right arm and leg. She has a mild intellectual disability. She i…
- USMLE Step 1 · hard2. A 26-year-old African American man comes to the physician because of a 3-day history of fatigue, back pain, and dark urine. One week ago, he developed a headache and was treated…
- USMLE Step 1 · hard · image3. A 34-year-old woman with a history of malabsorption presents with progressive fatigue, paresthesias, and impaired wound healing over 3 months. Laboratory studies reveal low seru…
- USMLE Step 1 · hard4. A 3 year old boy is brought to the emergency department with fever and lethargy. Blood cultures later grow Streptococcus pneumoniae. He has had multiple episodes of invasive pyo…
- USMLE Step 1 · hard5. A 54-year-old man with 10-year history of hypertension and type 2 diabetes presents for research evaluation of endothelial dysfunction. Current medications include metformin and…
- USMLE Step 1 · hard6. A 7-month-old infant presents with lethargy, seizures, and rapid breathing following an overnight fast during a viral illness. Vital signs show HR 128/min, RR 32/min, BP 90/58 m…
- USMLE Step 1 · easy7. A 22-year-old man presents with bloating, crampy abdominal pain, and watery diarrhea 30 minutes after consuming ice cream. He reports identical symptoms with milk but tolerates…
- USMLE Step 1 · easy8. A 68-year-old man with a 3-month history of weight loss and anemia presents with colon adenocarcinoma. Vital signs show BP 138/82, HR 92, RR 18, Temp 37.2°C. Laboratory findings…
- USMLE Step 1 · medium9. A biotechnology company engineers bacteria to produce human insulin by inserting a human gene into a plasmid vector. To generate compatible cohesive overhangs on both the plasmi…
- USMLE Step 1 · easy10. A 2-week-old male presents with tetralogy of Fallot, cleft palate, and recurrent candidal infections. Vital signs show HR 158/min, RR 42/min, SpO2 88% on room air, and temperatu…
- USMLE Step 1 · medium11. A 32-year-old woman presents with progressive difficulty releasing objects after gripping and daytime somnolence. Vital signs: BP 118/76, HR 82, RR 16, Temp 37°C, SpO2 98%. Exam…
- USMLE Step 1 · medium12. A 16-year-old boy presents with progressive tremor, dysarthria, and declining school performance over 6 months. Vital signs show BP 118/76, HR 88, RR 16, Temp 37.2°C, SpO2 98% o…
- USMLE Step 1 · medium13. A 9-month-old boy presents with failure to thrive, developmental delay, and recurrent seizures. Physical examination reveals hypothermia (36.2°C), sparse kinky hair, and skin la…
- USMLE Step 1 · medium14. A 7-year-old boy presents with declining school performance and progressive gait instability over 6 months. Vital signs show BP 108/65, HR 88, RR 20, temp 37°C, SpO2 98%. Examin…
- USMLE Step 1 · hard15. A 61-year-old groundskeeper with decades of pesticide exposure presents with progressive resting tremor, bradykinesia, and rigidity. Vital signs: BP 138/82, HR 62, RR 16, Temp 3…
- USMLE Step 1 · medium16. A 24-year-old laboratory worker is brought to the emergency department after sudden collapse during a chemical spill. He is tachypneic (RR 28/min) and confused. Vital signs show…
- USMLE Step 1 · medium17. A 37-year-old man presents with vomiting, watery diarrhea, and confusion 6 hours after ingesting contaminated herbal supplements. Vital signs show BP 102/68, HR 108, RR 20, temp…
- USMLE Step 1 · hard18. A 14-year-old boy presents with recurrent acute pancreatitis. Vital signs show BP 118/76 mmHg, HR 92 bpm, RR 18, temperature 37.2°C, SpO2 98% on room air. Fasting serum appears…
- USMLE Step 1 · medium19. An 8 month old boy has poor weight gain, chronic diarrhea, and abdominal distention. His parents report greasy foul smelling stools since starting formula feeds. Examination sho…
- USMLE Step 1 · medium20. A 5-year-old boy presents with recurrent episodes of severe abdominal pain and eruptive yellow papules over extensor surfaces. Vital signs show BP 110/68 mmHg, HR 98/min, RR 20/…
- USMLE Step 1 · medium21. A 31-year-old woman presents with recurrent jaundice during pregnancy (BP 118/76, HR 82, RR 16, Temp 37°C, SpO2 98%). Laboratory studies reveal elevated direct bilirubin at 3.2…
- USMLE Step 1 · medium22. A full-term newborn presents with severe jaundice within 12 hours of life. Vital signs show HR 160/min, RR 48/min, temperature 37.2°C. Total bilirubin is 28 mg/dL (predominantly…
- USMLE Step 1 · easy23. A 19 year old college student is evaluated after a routine laboratory panel shows total bilirubin of 2.5 mg/dL. He feels well but notes mild scleral icterus during exam week whe…
- USMLE Step 1 · medium24. A 49-year-old man with chronic hepatitis C presents with fragile skin and blistering lesions on the dorsal hands worsening with sun exposure. Vital signs: BP 128/82, HR 88, RR 1…