Metabolism USMLE Step 1 Practice Question
A 54-year-old man with 10-year history of hypertension and type 2 diabetes presents for research evaluation of endothelial dysfunction. Current medications include metformin and lisinopril. Vital signs show BP 158/92 mmHg, HR 78/min, RR 16/min, temp 37°C, SpO2 98% on room air. Laboratory studies reveal fasting glucose 156 mg/dL and elevated creatinine at 1.3 mg/dL. Vascular studies demonstrate reduced endothelial-derived vasodilator production synthesized from arginine. Which compound is significantly decreased?
Answer choices
- ASerotonin
- BDopamine
- CNitric oxideCorrect answer
- DHistamine
- EMelatonin
- FProstacyclin (PGI2)
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