Lipid Biochemistry USMLE Step 1 Practice Questions
102 board-style USMLE Step 1 questions in Biochemistry. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 · hard25. A 52-year-old woman with familial hypercholesterolemia presents with BP 138/86, HR 82, and fasting labs showing LDL 95 mg/dL (40% reduction on atorvastatin) but triglycerides pe…
- USMLE Step 1 · medium26. A 45-year-old man presents with eruptive xanthomas, hepatosplenomegaly, and recurrent pancreatitis. Vital signs show BP 138/82 mmHg, HR 88/min, RR 16/min, temp 37.2°C. Serum tri…
- USMLE Step 1 · hard27. A 56-year-old woman with primary biliary cholangitis presents with progressive jaundice and pruritus. Vital signs: BP 128/82, HR 88, RR 16, Temp 37°C, SpO2 98%. Laboratory studi…
- USMLE Step 1 · hard28. A 67-year-old man with peripheral vascular disease presents with chest discomfort. Vital signs: BP 158/92 mmHg, HR 88 bpm, RR 16, SpO2 98% on room air. He takes high-dose simvas…
- USMLE Step 1 · medium29. A 41-year-old man presents with acute pancreatitis and severe hypertriglyceridemia. Vital signs: BP 128/82, HR 98, RR 20, Temp 37.8°C, SpO2 98%. Serum triglycerides are 2800 mg/…
- USMLE Step 1 · medium30. A 29-year-old woman with systemic lupus erythematosus presents with fatigue and edema after 6 weeks of high-dose prednisone (60 mg daily) for lupus nephritis. Vital signs: BP 14…
- USMLE Step 1 · hard31. A 38-year-old man presents for lipid screening with BP 138/88, HR 82, RR 16, temp 37°C, SpO2 98%. Lipid panel reveals LDL cholesterol 240 mg/dL, triglycerides 350 mg/dL, and HDL…
- USMLE Step 1 · easy32. A 52-year-old woman with prior myocardial infarction at age 48 presents with chest pain. Vital signs: BP 142/88 mmHg, HR 92/min, RR 16/min, Temp 37°C, SpO2 98%. Laboratory studi…
- USMLE Step 1 · medium33. A 45-year-old man with a 20-year history of type 2 diabetes mellitus presents with fatigue and dyspnea on exertion. Vital signs: BP 152/88 mmHg, HR 92 bpm, RR 18/min, SpO2 98% o…
- USMLE Step 1 · medium34. A 67-year-old woman on chronic prednisone therapy for rheumatoid arthritis presents with fatigue. Vital signs: BP 148/92 mmHg, HR 88/min, RR 16/min, temp 37°C, SpO2 98%. Laborat…
- USMLE Step 1 · medium35. A 19-year-old man presents with recurrent tendon xanthomas, corneal opacities, and chest pain. Vital signs: BP 138/88, HR 92, RR 16, Temp 37°C, SpO2 98%. Total cholesterol is 68…
- USMLE Step 1 · medium36. A 51-year-old man with metabolic syndrome takes a fibrate for hypertriglyceridemia. Two weeks later, he develops myalgia and dark urine. Serum creatinine rises to 2.1 mg/dL from…
- USMLE Step 1 · hard37. A 28-year-old woman with severe hypertriglyceridemia (890 mg/dL) reports yellowing of her palms and severe abdominal pain. She is not pregnant and denies alcohol use. Genetic te…
- USMLE Step 1 · hard38. A 42-year-old woman presents with progressive jaundice and hepatosplenomegaly (liver 4 cm below costal margin). She reports ataxia and vertical supranuclear gaze palsy. Vital si…
- USMLE Step 1 · medium39. A 55-year-old man with familial hypercholesterolemia presents with persistent elevation of LDL cholesterol at 320 mg/dL despite maximal atorvastatin and ezetimibe therapy. Vital…
- USMLE Step 1 · medium40. A 7-year-old girl presents with orange-colored tonsils, lipemia retinalis, and recurrent pancreatitis. Vital signs: HR 98/min, BP 105/68 mmHg, RR 20/min, temp 37.2°C. Fasting la…
- USMLE Step 1 · medium41. A 62-year-old woman on atorvastatin 80 mg daily for 6 months presents with progressive myalgias and proximal muscle weakness. Vital signs: BP 138/82, HR 88, RR 16, Temp 37°C, Sp…
- USMLE Step 1 · hard42. A 3-year-old boy presents with failure to thrive, developmental delay, and progressive hepatosplenomegaly. Vital signs reveal HR 102/min, RR 24/min, temperature 37.2°C. Laborato…
- USMLE Step 1 · medium43. A 45-year-old man with a 20-year history of poorly controlled type 2 diabetes presents with fasting triglyceride level of 450 mg/dL and HDL of 28 mg/dL. He is not on statin ther…
- USMLE Step 1 · hard44. A 67-year-old man with atherosclerotic cardiovascular disease on pravastatin 40 mg daily presents with progressive cognitive decline and proximal muscle weakness over 3 weeks. V…
- USMLE Step 1 · hard45. A 35-year-old man of Mediterranean descent presents with orange discoloration of palms and soles and corneal infiltrates. Vital signs are stable (BP 128/82, HR 72, RR 14). Labor…
- USMLE Step 1 · medium46. A 28-year-old woman with recurrent pancreatitis presents with vital signs BP 118/76, HR 88, RR 16, Temp 37.2°C, SpO2 98%. Fasting serum triglycerides measure 2200 mg/dL with vis…
- USMLE Step 1 · medium47. A 45-year-old man with a 20-year history of type 2 diabetes presents with tendon xanthomas and eruptive skin xanthomas. Vital signs: BP 148/92 mmHg, HR 88 bpm, RR 16, temp 37°C.…
- USMLE Step 1 · medium48. A 67-year-old man with established coronary artery disease presents with BP 138/82, HR 78, on high-dose atorvastatin. PCSK9 inhibitor is initiated due to persistently elevated c…