Inflammation and Immune Pathology USMLE Step 1 Practice Questions
54 board-style USMLE Step 1 questions in Pathology. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 · hard1. A 34-year-old man with recent streptococcal pharyngitis develops two weeks of progressive dyspnea, orthopnea, and lower extremity edema. Echocardiography shows a dilated left ve…
- USMLE Step 1 · medium2. A 19-year-old male college student presents to the emergency department with a 12-hour history of fever, severe frontal headache, photophobia, and neck stiffness. On examination…
- USMLE Step 1 · hard3. A 72-year-old man with no significant past medical history undergoes elective total hip arthroplasty. On postoperative day 3, he develops fever (38.9°C), dyspnea, and a petechia…
- USMLE Step 1 · hard4. A 3-year-old boy presents with recurrent severe bacterial infections, failure to thrive, and oral candidiasis. Flow cytometry shows absent CD4+ T cells. Genetic testing reveals…
- USMLE Step 1 · medium5. A 45-year-old woman with systemic sclerosis presents with progressive skin thickening and dyspnea. Vital signs show BP 138/82, HR 98, RR 22, SpO2 92% on room air. Chest X-ray re…
- USMLE Step 1 · medium6. A 62-year-old man with a history of chronic hepatitis C develops jaundice, rash on the lower extremities, and glomerulonephritis with RBC casts in the urine. Serum cryoglobulins…
- USMLE Step 1 · medium7. A 28-year-old woman develops severe blistering and erosions of the skin and mucous membranes after sun exposure. Histopathology shows suprabasal acantholysis with IgG deposits a…
- USMLE Step 1 · medium8. A 52-year-old man with a 40 pack-year smoking history presents to the clinic with progressive dyspnea on exertion over the past 2 years and a chronic productive cough. He denies…
- USMLE Step 1 · easy9. A 7-year-old boy develops acute swelling of his face and extremities after eating shellfish. Within 15 minutes, he becomes short of breath with audible wheezing. His tongue is s…
- USMLE Step 1 · hard10. A 27-year-old woman with no significant past medical history presents with fever (38.9°C), severe thrombocytopenia (15,000/μL), microangiopathic hemolytic anemia (hemoglobin 7.2…
- USMLE Step 1 · medium11. A 34-year-old man presents to the emergency department with a 3-day history of jaundice, dark urine, and exertional dyspnea. He denies recent infections, new medications, or tra…
- USMLE Step 1 · medium12. A 41-year-old woman with rheumatoid arthritis treated with etanercept presents with productive cough, fever (38.9°C), and dyspnea. Vital signs show BP 128/82, HR 102, RR 22, SpO…
- USMLE Step 1 · hard13. A 19-year-old male college student presents to the emergency department with a 12-hour history of fever (39.4°C), severe headache, and photophobia. On examination, he has a pete…
- USMLE Step 1 · medium14. A 72-year-old man with a 10-year history of hypertension (previously on no medications) presents to the emergency department with acute severe flank pain, gross hematuria, and d…
- USMLE Step 1 · medium15. A 52-year-old man with no smoking history presents with 8 weeks of progressive dyspnea, low-grade fever, and fatigue. Chest X-ray shows bilateral hilar lymphadenopathy with scat…
- USMLE Step 1 · medium16. A 6-year-old boy presents with recurrent skin and respiratory infections caused by Staphylococcus aureus and Serratia marcescens. Flow cytometry reveals normal T cell and B cell…
- USMLE Step 1 · hard17. A 28-year-old woman presents with a 6-month history of progressive dry eyes and dry mouth. She has a past medical history of Hashimoto thyroiditis diagnosed 3 years ago. Physica…
- USMLE Step 1 · medium18. A 45-year-old man with a history of recurrent sinusitis and lower respiratory tract infections presents with hemoptysis and glomerulonephritis. Serum tests show elevated creatin…
- USMLE Step 1 · medium19. A 32-year-old woman presents with a 3-month history of polyarthralgia, photosensitivity, and a malar rash. Vital signs show BP 128/82 mmHg, HR 88/min, RR 16/min, temp 37.2°C, Sp…
- USMLE Step 1 · hard20. A 19-year-old previously healthy male college student presents to the emergency department with a 12-hour history of fever (39.8°C), severe frontal headache, and neck stiffness.…
- USMLE Step 1 · medium21. A 52-year-old man with a 30-year occupational history of asbestos exposure presents to the pulmonary clinic with progressive dyspnea, chest pain, and persistent dry cough. Vital…
- USMLE Step 1 · medium22. A 32-year-old woman presents to rheumatology clinic with a 4-month history of symmetric polyarthritis affecting her hands, wrists, and knees. She reports morning stiffness lasti…
- USMLE Step 1 · medium23. A 41-year-old woman presents with acute dyspnea, hemoptysis, and dyspnea on exertion. Vital signs show BP 148/92 mmHg, HR 118/min, RR 22/min, SpO2 88% on room air. Laboratory st…
- USMLE Step 1 · hard24. A 19-year-old woman presents with fever (39.2°C), petechial rash, and meningitis. Vitals show HR 118/min, BP 94/62 mmHg, RR 22/min, SpO2 98% on room air. Blood cultures pending;…