Inflammation and Immune Pathology USMLE Step 1 Practice Question
A 45-year-old man with a history of recurrent sinusitis and lower respiratory tract infections presents with hemoptysis and glomerulonephritis. Serum tests show elevated creatinine and proteinuria. Imaging reveals pulmonary infiltrates. Biopsy shows necrotizing vasculitis of small vessels with granulomatous inflammation. Which of the following antibodies is most likely to be positive?
Answer choices
- AAnti-glomerular basement membrane antibodies
- BPerinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA) against myeloperoxidase
- CAnti-phospholipid antibodies
- DAnti-topoisomerase I antibodies
- ECytoplasmic anti-neutrophil cytoplasmic antibodies (c-ANCA) against proteinase 3Correct answer
- FAnti-U1 ribonucleoprotein antibodies
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