CNS Pharmacology USMLE Step 1 Practice Questions
55 board-style USMLE Step 1 questions in Pharmacology. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 · easy25. A 52-year-old obese man presents to his primary care physician after routine bloodwork revealed a fasting glucose of 187 mg/dL and a hemoglobin A1c of 8.2%. He has a BMI of 34 k…
- USMLE Step 1 · medium26. A 46-year-old man with cirrhosis presents with hematemesis and hypotension. Vital signs show BP 85/52 mmHg, HR 118/min, RR 20/min, temperature 37.2°C, and SpO2 98% on room air.…
- USMLE Step 1 · hard27. A 59-year-old man with a known history of small cell lung carcinoma, currently undergoing chemotherapy, presents to the emergency department with a 3-day history of progressive…
- USMLE Step 1 · hard28. A 12-year-old boy is brought to his pediatrician by his mother, who reports that he has experienced easy bruising and recurrent nosebleeds since early childhood. She notes that…
- USMLE Step 1 · medium29. A 34-year-old man presents to a base camp medical station after ascending rapidly from 1,400 m to 4,200 m over 18 hours during a Himalayan trekking expedition. He reports a thro…
- USMLE Step 1 · medium30. A 62-year-old woman with unstable angina undergoes urgent percutaneous coronary intervention. She receives an intravenous antiplatelet agent and subsequently develops a platelet…
- USMLE Step 1 · easy31. A 64-year-old man presents with acute anterior wall myocardial infarction (troponin I 4.2 ng/mL). He undergoes coronary stent placement and is started on aspirin. Vital signs: B…
- USMLE Step 1 · medium32. A 74-year-old woman with nonvalvular atrial fibrillation presents with HR 92 bpm, BP 138/82 mmHg, and no signs of heart failure on examination. Recent INR monitoring shows varia…
- USMLE Step 1 · medium33. A 58-year-old man presents 90 minutes after sudden onset of right arm weakness and expressive aphasia. Vital signs: BP 158/92, HR 98, RR 16, temp 37.2°C, SpO2 98% on room air. H…
- USMLE Step 1 · hard34. A 60-year-old man with a history of anterior myocardial infarction two years ago presents to his cardiologist reporting palpitations, mild dyspnea on exertion, and occasional li…
- USMLE Step 1 · easy35. A 22-year-old man with no significant past medical history presents to the emergency department with sudden onset palpitations that began 45 minutes ago while he was at rest. He…
- USMLE Step 1 · hard36. A 67-year-old man treated with a class III antiarrhythmic for recurrent ventricular tachycardia presents with progressive dyspnea and cough over six months. Vital signs show HR…
- USMLE Step 1 · hard37. A 28-year-old man with Wolff-Parkinson-White syndrome presents with episodic palpitations and is found to have antidromic atrioventricular reentrant tachycardia. Vital signs: BP…
- USMLE Step 1 · medium38. A 48-year-old man with refractory hypertension uncontrolled on lisinopril and hydrochlorothiazide is started on a potent arteriolar vasodilator. Current vital signs show BP 138/…
- USMLE Step 1 · medium39. A 36-year-old woman with severe chronic hypertension has been treated with hydralazine 100 mg twice daily for six months. She now presents with arthralgias, myalgias, low-grade…
- USMLE Step 1 · easy40. A 29-year-old pregnant woman at 24 weeks gestation presents to her obstetric clinic for a routine prenatal visit, during which persistent hypertension is noted on two separate r…
- USMLE Step 1 · medium41. A 55-year-old man presents with an inferior wall myocardial infarction complicated by symptomatic bradycardia. Vital signs show BP 88/56 mmHg, HR 42 bpm, RR 16, temp 37°C, SpO2…
- USMLE Step 1 · medium42. A 63-year-old man with urosepsis presents with hypotension (BP 78/52 mmHg), tachycardia (HR 118 bpm), tachypnea (RR 22), fever (39.2°C), and altered mental status despite aggres…
- USMLE Step 1 · medium43. A 70-year-old man with a history of hypertension and type 2 diabetes mellitus is brought to the emergency department and subsequently hospitalized for acute decompensated heart…
- USMLE Step 1 · easy44. A 17-year-old boy with known peanut allergy presents to the emergency department minutes after eating a cookie at school. He has diffuse urticaria, wheezing, and angioedema of t…
- USMLE Step 1 · easy45. A 68-year-old woman presents with a 6-month history of urinary urgency, frequency, and nocturia. Vital signs are stable (BP 138/82, HR 78, RR 16, Temp 37°C). Urinalysis is negat…
- USMLE Step 1 · easy46. A 24-year-old woman with a history of severe motion sickness is planning a transatlantic cruise lasting seven days. Her physician prescribes a transdermal patch applied behind t…
- USMLE Step 1 · medium47. A 65-year-old man with hypertension (BP 158/92 mmHg, HR 78) begins once-daily oral antihypertensive therapy. He asks when the medication will stabilize at near-constant average…
- USMLE Step 1 · medium48. A 45-year-old woman with moderate osteoarthritis presents with knee pain (7/10). Vital signs: BP 128/82, HR 82, RR 16, Temp 37.2°C, SpO2 98%. Her rheumatologist compares two exp…