CNS Pharmacology USMLE Step 1 Practice Question
A 36-year-old woman with severe chronic hypertension has been treated with hydralazine 100 mg twice daily for six months. She now presents with arthralgias, myalgias, low-grade fever (38.2°C), and a malar-like rash across her cheeks. Vital signs show BP 158/102 mmHg, HR 88, RR 16, and SpO2 98%. Laboratory testing reveals positive anti-histone antibodies, elevated ESR (65 mm/hr), and a normal complement level. Physical examination reveals mild bilateral wrist tenderness without synovial swelling. She has no photosensitivity or discoid lesions. Which medication most likely caused this drug-induced lupus-like syndrome?
Answer choices
- AHydrochlorothiazide
- BAmlodipine
- CLosartan
- DHydralazineCorrect answer
- ENitroglycerin
- FLisinopril
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