CNS Pharmacology USMLE Step 1 Practice Questions
55 board-style USMLE Step 1 questions in Pharmacology. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 · medium1. A 24-year-old woman comes to the emergency department because of severe upper abdominal pain and nausea for six hours. She describes the pain as constant, radiating to her back,…
- USMLE Step 1 · hard2. A 68-year-old man with mild cognitive impairment is started on donepezil 5 mg daily for suspected early Alzheimer disease. His past medical history is significant for hypertensi…
- USMLE Step 1 · easy3. A 32-year-old woman with generalized anxiety disorder presents to the emergency department after becoming unresponsive at a social event. She has taken alprazolam 2 mg daily for…
- USMLE Step 1 · medium4. A 45-year-old man with a history of chronic migraines is started on topiramate 100 mg daily for prophylaxis. Two weeks into treatment, his wife reports that he seems unusually f…
- USMLE Step 1 · medium5. A 72-year-old woman with a 6-month history of insomnia presents to her primary care physician complaining of a concerning episode the night after starting zolpidem 10 mg at bedt…
- USMLE Step 1 · hard6. A 55-year-old man with major depressive disorder has been treated with fluoxetine 40 mg daily for 3 months with good symptom control. His psychiatrist plans to initiate phenelzi…
- USMLE Step 1 · easy7. A 35-year-old man with no prior psychiatric history presents to the emergency department with acute-onset disorganized speech, paranoid delusions, and agitation. Vital signs are…
- USMLE Step 1 · medium8. A 28-year-old woman with bipolar I disorder has been stable on lithium 900 mg daily for 6 months. Three days ago, she developed acute gastroenteritis with persistent vomiting an…
- USMLE Step 1 · medium9. A 67-year-old man with a 5-year history of Parkinson disease has been stable on levodopa/carbidopa 25/100 mg four times daily for the past 2 years. Due to a pharmacy dispensing…
- USMLE Step 1 · medium10. A 42-year-old woman with generalized anxiety disorder has been stable on sertraline 100 mg daily for 2 years. She presents to the emergency department 3 days after starting fluc…
- USMLE Step 1 · hard11. A 71-year-old man with Alzheimer disease has taken donepezil 10 mg daily for 4 weeks. He presents with syncope, BP 98/62 mmHg, HR 48 bpm, RR 16, and SpO2 98% on room air. ECG sh…
- USMLE Step 1 · medium12. A 24-year-old man with schizophrenia treated with risperidone 4 mg daily for 1 year presents with erectile dysfunction and galactorrhea. His girlfriend also reports amenorrhea f…
- USMLE Step 1 · medium13. A 38-year-old woman with chronic migraine headaches takes topiramate 100 mg daily for prophylaxis. She presents with progressive cognitive slowing, memory impairment, and diffic…
- USMLE Step 1 · medium14. A 45-year-old man presents with a 2-year history of nightly zolpidem 10 mg use for chronic insomnia. He reports increasing daytime somnolence, two episodes of complex sleep beha…
- USMLE Step 1 · medium15. A 19-year-old male presents to the emergency department with acute onset agitation, palpitations, and tremor 3 hours after ingesting unknown pills at a party. He reports feeling…
- USMLE Step 1 · medium16. A 28-year-old woman with a 2-year history of generalized anxiety disorder presents to discuss medication management in anticipation of pregnancy. She has been stable on lorazepa…
- USMLE Step 1 · medium17. A 67-year-old man with Parkinson disease treated with levodopa/carbidopa 25/100 mg four times daily for 5 years presents with involuntary writhing movements of his extremities a…
- USMLE Step 1 · medium18. A 52-year-old man with treatment-resistant major depressive disorder has been taking phenelzine 45 mg daily for 8 months with adequate symptom control. His psychiatrist adds ser…
- USMLE Step 1 · medium19. A 34-year-old woman with bipolar I disorder has been stable on lithium 900 mg daily for 3 years. She presents with tremor, confusion, and ataxia. Temperature is 37.1°C, blood pr…
- USMLE Step 1 · hard20. A 55-year-old woman presents to her oncologist for follow-up after being diagnosed with invasive ductal carcinoma of the right breast six months ago. Immunohistochemical stainin…
- USMLE Step 1 · medium21. A 41-year-old woman with systemic lupus erythematosus has taken high-dose prednisone for 6 months. She presents with proximal muscle weakness, easy bruising, and recurrent oral…
- USMLE Step 1 · medium22. A 27-year-old woman at 9 weeks of gestation presents to her obstetrician complaining of a 6-week history of heat intolerance, fine resting tremor, unintentional weight loss of 8…
- USMLE Step 1 · medium23. A 49-year-old woman with a 12-year history of obesity and type 2 diabetes presents to her primary care physician for a routine follow-up. Her current medications include metform…
- USMLE Step 1 · medium24. A 68-year-old man with a 12-year history of type 2 diabetes mellitus and stage 3 chronic kidney disease is found unresponsive by his wife at home in the early morning. Emergency…