Toxicology USMLE Step 1 Practice Question
A 23-year-old woman presents 12 hours after intentional acetaminophen overdose. She reports nausea and vomiting but denies abdominal pain. Vital signs: BP 118/76, HR 102, RR 16, Temp 37.2°C, SpO2 98%. Physical examination reveals no jaundice or hepatomegaly. Laboratory studies show serum acetaminophen level of 85 μg/mL (toxic range). AST and bilirubin remain normal. Which treatment is most appropriate to prevent severe hepatic injury?
Answer choices
- AActivated charcoal only after 24 hours
- BN acetylcysteineCorrect answer
- CFomepizole
- DNaloxone
- EDeferasirox
- FActivated charcoal
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