Pituitary Disorders USMLE Step 1 Practice Question
A 48-year-old woman presents with progressive shoe size increase, coarse facial features, and fasting hyperglycemia. Vital signs show BP 148/92 mmHg, HR 78/min, RR 16/min, temperature 37°C, and SpO2 98% on room air. Serum IGF-1 is markedly elevated at 650 ng/mL (normal <300). Fasting glucose is 156 mg/dL. She denies headaches or visual disturbances. Which additional finding would most strongly confirm the diagnosis?
Answer choices
- ASuppression of cortisol after low dose dexamethasone
- BFailure of growth hormone suppression after oral glucose challengeCorrect answer
- CHigh aldosterone to renin ratio
- DLow prolactin level
- EGrowth hormone suppression after oral glucose challenge
- FElevated insulin-like growth factor binding protein-3 (IGFBP-3) with normal growth hormone levels
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