Neurodegenerative Diseases USMLE Step 1 Practice Question
A 34-year-old man presents with progressive bilateral leg weakness and paresthesias beginning one week after acute diarrheal illness. Vital signs: BP 118/76, HR 92, RR 18, Temp 37.2°C, SpO2 98% on room air. Physical examination reveals areflexia in both lower extremities; upper extremity reflexes remain intact. Serum electrolytes and glucose are normal. CSF protein is markedly elevated at 89 mg/dL with normal cell count. Which of the following is the most likely diagnosis?
Answer choices
- AMyasthenia gravis
- BMultiple sclerosis
- CAmyotrophic lateral sclerosis
- DPoliomyelitis
- EGuillain-Barre syndromeCorrect answer
- FChronic inflammatory demyelinating polyradiculoneuropathy
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