Neurodegenerative Diseases USMLE Step 1 Practice Question
A 58-year-old man presents with progressive behavioral changes over 1 year, including social inappropriateness, impulsivity, and emotional blunting. Vital signs are stable (BP 128/82, HR 76, RR 14). Mini-Cog score is 27/30, demonstrating relatively preserved cognition and memory. MRI brain shows focal anterior temporal and frontal lobe atrophy. He denies recent head trauma or substance abuse. Which of the following is the most likely diagnosis?
Answer choices
- ANormal pressure hydrocephalus
- BFrontotemporal dementiaCorrect answer
- CAlzheimer disease
- DHuntington disease
- ELewy body dementia
- FProgressive supranuclear palsy with gaze palsy
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