Metabolism USMLE Step 1 Practice Questions
110 board-style USMLE Step 1 questions in Biochemistry. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 · medium73. A 5-year-old male with growth retardation and mild intellectual impairment has an enlarged thyroid. His serum thyroid-stimulating hormone (TSH) level is 4.3 mU/L (normal: 0.1-4.…
- USMLE Step 1 · medium74. A neonate who initially appears healthy develops vomiting, diarrhea, abdominal pain, and hypoglycemia when weaning is attempted. Other features include a generalized metabolic d…
- USMLE Step 1 · medium75. A 57-year-old sales representative for a biotechnology firm has a history of alcohol abuse and hyperuricemia. He attends an out-of-town conference and gorges himself on appetize…
- USMLE Step 1 · medium76. A 28-year-old male comes to the physician because of intermittent right upper quadrant pain that extends to the inferior tip of his scapula. Laboratory studies show mild anemia,…
- USMLE Step 1 · medium77. The enzyme hypoxanthine guanine phosphoribosyl transferase (HGPRT) isolated from a child with Lesch-Nyhan syndrome is compared with HGPRT isolated from a healthy control individ…
- USMLE Step 1 · medium78. A 52-year-old female is diagnosed with breast cancer. After discussing treatment options with her oncologist, she decides to turn to the Internet for advice. In a cancer surviva…
- USMLE Step 1 · medium79. A 2-month-old male is evaluated for failure to thrive. As the pediatrician is examining the patient, she witnesses a seizure. Physical examination is remarkable for hepatomegaly…
- USMLE Step 1 · medium80. A 5-day-old infant suffers a seizure and is rushed to the emergency department. The mother reports that the infant was healthy when born but has become extremely lethargic, and…
- USMLE Step 1 · medium81. A 25-year-old female with type 1 diabetes mellitus has maintained good glycemic control for several years. Recently she has gained 10 pounds and joined a group exercise program.…
- USMLE Step 1 · medium82. A 34-year-old male with newly diagnosed hyperlipidemia presents with fatigue and recurrent infections. Vital signs: BP 128/82, HR 88, RR 16, Temp 37.2°C, SpO2 98%. Laboratory st…
- USMLE Step 1 · medium83. A 28-year-old woman with known pyruvate kinase deficiency presents with fatigue and jaundice. Vital signs show BP 118/76, HR 102, RR 18, Temp 37.2°C, SpO2 98%. Laboratory studie…
- USMLE Step 1 · medium84. A 3-year-old female who is small for her age has had multiple hypoglycemic episodes associated with moderate fasting during periods of illness. In her most recent episode associ…
- USMLE Step 1 · medium85. A 28-year-old woman with type 1 diabetes presents with fatigue and polyuria. Vital signs: BP 118/76, HR 92, RR 18, Temp 37°C, SpO2 98%. She requires 0.8 units/kg/day insulin. A…
- USMLE Step 1 · medium86. A 12-year-old boy with short stature presents with fasting hypoglycemia (45 mg/dL), hepatomegaly, and a bleeding diathesis. Vital signs show BP 95/60, HR 102, RR 18, temp 37°C,…
- USMLE Step 1 · medium87. A 4-year-old male is brought to the pediatrician because of gastroenteritis for 3 days, followed by a brief generalized seizure that left him semicomatose. The blood glucose lev…
- USMLE Step 1 · medium88. A 2-year-old male presents with progressive neurological deterioration, developmental regression, and cherry-red macular spots on ophthalmologic examination. Vital signs show HR…
- USMLE Step 1 · medium89. Methotrexate is used as therapy for rheumatoid arthritis, but has many side effects related to competitive inhibition of the enzyme dihydrofolate reductase. These side effects c…
- USMLE Step 1 · medium90. An infant receives an exchange blood transfusion due to severe neonatal jaundice. Red blood cell transfusion is required monthly, and at 6 months of age, a splenectomy is perfor…
- USMLE Step 1 · medium91. A 21-year-old female presents to the emergency department with complaints of breathing difficulty, nausea, and vomiting for the past 4 hours. History reveals that the patient ha…
- USMLE Step 1 · medium92. A 4-year-old boy with developmental delay presents with self-injurious behavior, repeatedly striking his head against walls and severely biting his fingertips requiring bandagin…
- USMLE Step 1 · medium93. A 5-year-old boy presents with temporary muscle weakness and cramping after exercise. Vital signs show HR 98/min, BP 105/68 mmHg, RR 20/min, and normal temperature. Serum creati…
- USMLE Step 1 · medium94. A 45-year-old researcher is purifying lysosomal proteins from cultured hepatocytes for functional studies. He uses affinity chromatography with a column matrix conjugated to an…
- USMLE Step 1 · medium95. A 2-day-old male neonate presents with microcephaly, micrognathia, cleft palate, ambiguous genitalia, and syndactyly of the second and third toes bilaterally. Vital signs show H…
- USMLE Step 1 · medium96. A 8-year-old boy presents with hepatomegaly, bilateral renal enlargement, gout, and eruptive xanthomas. Vital signs show BP 118/76 mmHg, HR 102/min, RR 20/min, temperature 37.2°…