Lipid Biochemistry USMLE Step 1 Practice Question
A 45-year-old man with diabetes mellitus type 2 presents with recurrent pancreatitis. Laboratory studies show triglycerides of 1,200 mg/dL and total cholesterol of 680 mg/dL. His father died of myocardial infarction at age 52. Genetic testing reveals a mutation in the lipoprotein lipase gene. Which of the following pathways is primarily impaired in this patient?
Answer choices
- ASynthesis of apolipoprotein B-100 in hepatocytes
- BUptake of LDL particles via LDL receptor-mediated endocytosis
- CHydrolysis of triglycerides in chylomicrons and VLDL by lipoprotein lipaseCorrect answer
- DEsterification of cholesterol in HDL by LCAT
- EConversion of VLDL to IDL by hepatic triglyceride lipase
- FUptake of triglyceride-rich lipoproteins by lipoprotein receptors in adipose and muscle tissue
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