Lipid Biochemistry USMLE Step 1 Practice Question
A 38-year-old woman presents with recurrent eruptive xanthomas and lipemia retinalis. Vital signs show BP 145/92 mmHg, HR 88/min, RR 16/min, temp 37°C, SpO2 98%. Laboratory studies reveal severe hypertriglyceridemia at 5200 mg/dL with normal LDL cholesterol of 95 mg/dL. Abdominal imaging shows no pancreatic inflammation. Her 2-year-old daughter has identical clinical and biochemical findings. Genetic testing confirms apolipoprotein C-II gene mutations in both. Which lipoprotein class is primarily elevated?
Answer choices
- AHDL and lipoprotein(a)
- BOnly intestinal chylomicrons
- CChylomicrons and VLDLCorrect answer
- DOnly VLDL remnants
- ELDL and IDL
- FOnly lipoprotein(a) and intermediate-density lipoproteins
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