Lipid Biochemistry USMLE Step 1 Practice Question
A 19-year-old woman with history of recurrent pancreatitis is found to have fasting triglycerides of 650 mg/dL and chylomicrons visible on plasma electrophoresis. Her apoC-II levels are normal, and lipoprotein lipase activity is absent. Genetic testing reveals mutations in the LPL gene. Which of the following pathophysiologic processes is directly impaired in this patient?
Answer choices
- AEsterification of free fatty acids in adipose tissue
- BHepatic synthesis of very low-density lipoprotein
- CHepatic uptake of chylomicron remnants
- DIntestinal synthesis of chylomicrons
- EHydrolysis of triglycerides in chylomicrons and VLDL at the capillary endotheliumCorrect answer
- FApolipoprotein B-100 synthesis in the liver
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