Lipid Biochemistry USMLE Step 1 Practice Question
A 21-year-old male participates in a nutrition study. Two hours after consuming a high-carbohydrate meal, he has elevated serum insulin levels (18 mIU/L; normal fasting <12). Vital signs are normal: BP 118/76, HR 82, RR 16, Temp 98.6°F, SpO2 99%. Blood glucose is 145 mg/dL. He denies medication use and has no family history of diabetes. Which of the following changes is most likely occurring in his hepatocytes at this time?
Answer choices
- AActivation of hormone sensitive lipase increases lipolysis
- BIncreased glucagon promotes ketogenesis
- CDecreased fatty acid synthase activity reduces triglyceride synthesis
- DDecreased acetyl CoA carboxylase activity increases beta oxidation
- EIncreased malonyl CoA inhibits carnitine palmitoyltransferase ICorrect answer
- FIncreased AMP-activated protein kinase activity enhances glucose oxidation
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