Lipid Biochemistry USMLE Step 1 Practice Question
A 46-year-old man presents with progressive exertional chest pain. Vital signs show BP 158/94 mmHg, HR 92/min, RR 16/min, SpO2 98% on room air. Physical examination reveals yellow plaques over elbows and palmar creases. Fasting lipid panel demonstrates total cholesterol 520 mg/dL and triglycerides 680 mg/dL; LDL 380 mg/dL. EKG shows no acute ischemic changes. He denies statin use. Accumulation of which particles most likely causes this disorder?
Answer choices
- ALipoprotein(a) only
- BChylomicron and VLDL remnantsCorrect answer
- CLDL particles only
- DChylomicrons only
- EHDL particles
- FApolipoprotein B-100 aggregates
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