Lipid Biochemistry USMLE Step 1 Practice Question
A 29 year old man presents for evaluation of Achilles tendon thickening. His father had a myocardial infarction at age 38. Examination shows tendon xanthomas over both Achilles tendons. Fasting lipid panel shows markedly elevated LDL cholesterol with normal triglycerides. Which of the following is the most likely underlying defect?
Answer choices
- ADefective apolipoprotein E mediated remnant clearance
- BDefective apolipoprotein CII activation of lipoprotein lipase
- CDefective LDL receptor mediated endocytosisCorrect answer
- DDefective microsomal triglyceride transfer protein
- EDeficient lecithin cholesterol acyltransferase
- FFamilial defective apoB-100
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