Inflammation and Immune Pathology USMLE Step 1 Practice Question
A 38-year-old woman presents with acute right lower quadrant pain, fever (38.9°C), tachycardia (102 bpm), and tachypnea (18 breaths/min). Physical examination reveals rebound tenderness. Labs show WBC 14,200/μL with left shift; CT abdomen demonstrates appendiceal wall thickening with periappendiceal fat stranding. She denies recent antibiotic use. Histopathology of the resected appendix reveals dense neutrophilic infiltration within the mucosa and submucosa. Which cytokine is the major chemokine directly responsible for neutrophil recruitment to this inflamed tissue?
Answer choices
- AIL 18
- BIL 4
- CIL 17
- DIL 8Correct answer
- EIL 21
- FTNF-α
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