Inflammation and Immune Pathology USMLE Step 1 Practice Question
A 29-year-old woman presents with fever (38.2Ā°C), bilateral hilar lymphadenopathy on chest X-ray, and erythema nodosum. Lymph node biopsy reveals noncaseating granulomas with multinucleated giant cells and activated macrophages. Serum calcium is elevated at 11.8 mg/dL. ACE level is elevated. She denies cough and has normal pulmonary function tests. She takes no immunosuppressive medications. Which cytokine relationship is most important in formation of the multinucleated giant cells and activated macrophages in this granulomatous lesion?
Answer choices
- AIL 12 from macrophages promoting Th1 cells that produce IFN gammaCorrect answer
- BIL 4 from Th2 cells stimulating eosinophils
- CIL 10 from regulatory T cells suppressing macrophage activation
- DTGF beta from fibroblasts inhibiting collagen synthesis
- EIL 5 from mast cells promoting B cell maturation
- FIL 6 from endothelial cells promoting Th17 cell differentiation and neutrophil recruitment
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