Histology USMLE Step 1 Practice Question
A 51-year-old woman with a three-year history of progressive dysphagia and chronic GERD presents with dysphagia to solids. Vital signs: BP 128/82, HR 88, RR 16, Temp 37.2°C, SpO2 98%. Esophageal biopsy of the distal esophagus shows replacement of normal stratified squamous epithelium with columnar epithelium containing goblet cells. Barium swallow reveals no strictures. She denies current chest pain. Which histologic finding is most consistent with this diagnosis?
Answer choices
- AScleroderma with submucosal fibrosis
- BReflux esophagitis with acute inflammation
- CBarrett esophagusCorrect answer
- DEsophageal adenocarcinoma
- EAchalasia with megaesophagus
- FPlummer-Vinson syndrome with esophageal webs
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