Histology USMLE Step 1 Practice Question
A 17-year-old boy presents with a 3-month history of chronic diarrhea and 8-kg weight loss. Vital signs show HR 92/min, BP 110/68 mmHg, temperature 37.2°C. Colonoscopy appears normal, but ileoscopy reveals patchy mucosal inflammation with aphthous ulcers. Laboratory studies show hemoglobin 11.2 g/dL and elevated fecal calprotectin. Normal tissue from the terminal ileum would be expected to contain which of the following histologic features?
Answer choices
- AStratified squamous epithelium
- BNo villi and many goblet cells
- CNumerous Peyer patchesCorrect answer
- DParietal and chief cells
- ESubmucosal Brunner glands
- FColumnar epithelium with enteroendocrine cells but no organized lymphoid follicles
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