Hepatobiliary Disease USMLE Step 1 Practice Question
A 48-year-old woman presents with progressive pruritus and fatigue for 3 months. Vital signs: BP 118/76, HR 88, RR 16, Temp 98.6°F, SpO2 98% on room air. Laboratory studies reveal alkaline phosphatase 312 U/L, total cholesterol 284 mg/dL, and serum anti-mitochondrial antibodies positive. Liver biopsy demonstrates granulomatous inflammation of intrahepatic bile ducts. She denies recent alcohol use. Which of the following best describes the underlying pathologic lesion?
Answer choices
- AFibrosing inflammation of intrahepatic and extrahepatic bile ducts associated with ulcerative colitis
- BMassive hepatocyte necrosis after acetaminophen overdose
- CAutoimmune destruction of small intrahepatic bile ductsCorrect answer
- DCopper deposition due to ATP7B mutation
- EObstruction of the common bile duct by a pancreatic head mass
- FViral-induced hepatitis with subsequent cirrhosis and portal hypertension
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