Hepatobiliary Disease USMLE Step 1 Practice Question
A 52-year-old man presents with progressive fatigue, arthralgias, and skin hyperpigmentation. Vital signs show BP 128/82, HR 88, RR 16, temperature 37°C, SpO2 98%. Laboratory studies reveal serum ferritin 850 ng/mL, transferrin saturation 92%, and elevated transaminases. Abdominal ultrasound demonstrates hepatomegaly with cirrhotic features. He denies abdominal pain or jaundice. Which organ system manifestation is most likely if this disease progresses untreated?
Answer choices
- ALead pipe colon from mucosal inflammation
- BPruritus from autoimmune destruction of intrahepatic bile ducts
- CRestrictive or dilated cardiomyopathyCorrect answer
- DCopper deposition in the basal ganglia
- EFlushing and wheezing from serotonin excess
- FAdrenal insufficiency from iron overload
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